湿疹与抑郁症的孟德尔随机化研究

徐小然; 杨子涵; 宁竟; 孙付童语; 谭曦

doi:10.16766/j.cnki.issn.1674-4152.003786

湿疹与抑郁症的孟德尔随机化研究

doi: 10.16766/j.cnki.issn.1674-4152.003786

1.
北京中医药大学生命科学学院，北京 100029
2.
北京中医药大学管理学院
3.
北京中医药大学深圳医院, 广东深圳 518100

基金项目:

国家自然科学基金面上项目 81973978

广东省深圳市基础研究专项(自然科学基金)面上项目 JCYJ20210324135413036

详细信息

通讯作者:
谭曦, E-mail: tanxi@.bucm.edu.cn

中图分类号: R758.23 R749.4
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- 文章访问数: 14
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- PDF下载量: 2
- 被引次数: 0
出版历程
- 收稿日期: 2024-05-12
- 网络出版日期: 2025-01-20

Mendelian randomization study of eczema and depression

1.
Academy of Life Science, Beijing University of Chinese Medicine, Beijing 100029, China

摘要

摘要: 目的湿疹与抑郁症之间的关系备受关注，然而二者之间的因果关联尚不明确。本研究采用孟德尔随机法(MR)研究湿疹与抑郁症之间是否存在因果关系。方法在公开的全基因组关联研究(GWAS)的集合数据集中选出湿疹与抑郁症的基因型数据，湿疹为暴露因素，抑郁症为结局变量。样本量为40 835例。利用MR对所选样本进行基因型分析，其中工具变量为与湿疹疾病有强相关性的基因位点。采用比值比(OR)作为估计指标，效应值β判断两者之间的关联方向。同时进行异质性检验、敏感性分析以及水平多效性检验。结果逆方差加权法分析结果显示，湿疹与抑郁发生之间呈正相关关系(OR=1.011，95% CI：1.001~1.022，P=0.037)；加权中位数回归分析得到了相似结果(OR=1.012，95% CI: 1.001~1.023，P=0.029)。Cochran's Q检验显示结果存在显著异质性(P < 0.05)，但通过随机效应模型分析得到P=0.037且β=0.011，证明二者存在正向因果关系。此外，漏斗图和Mr-Egger截距未观察到水平多效性。结论研究结果表明，湿疹与抑郁发生之间可能存在正向因果关系。
- 湿疹 /
- 抑郁症 /
- 孟德尔随机化
Abstract: Objective The relationship between eczema and depression has received much attention, yet the causal association between the two is unclear. Therefore, Mendelian randomization (MR) was used to investigate whether there is a causal relationship between eczema and depression. Methods Genotypic data of eczema and depression were selected from the publicly available pooled dataset of the Genome-wide association study (GWAS), with eczema as the exposure factor and depression as the outcome variable. The selected samples were genotyped using MR, where the instrumental variables were genetic loci with a strong correlation with eczema disease. The odds ratio (OR) was used as an estimator, and the effect value β judged the direction of the association between the two. Heterogeneity test, sensitivity analysis, and horizontal multiple validity test were also performed. Results Inverse variance weighted method analysis showed a positive correlation between eczema and the occurrence of depression and yielded an OR of 1.011, 95% CI: 1.001-1.022, P=0.037; weighted median regression analysis yielded similar results (OR=1.012, 95% CI: 1.001-1.023, P=0.029). Cochran ' s Q test showed significant heterogeneity of the results (P < 0.05), but the analysis of the random effects model yielded P=0.037 and β=0.011, which proved that there was a positive causal relationship. In addition, no horizontal pleiotropy was observed for the funnel plot and Mr-Egger intercept. Conclusion The findings suggest a possible positive causal relationship between eczema and the occurrence of depression.
- Eczema /
- Depression /
- Mendelian randomization

HTML全文

图 1 两样本孟德尔随机化模型

Figure 1. Two-Sample Mendelian randomization model

下载: 全尺寸图片幻灯片

图 2 湿疹和抑郁症结果的森林图

Figure 2. The forest plot of eczema and depression outcomes

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图 3 湿疹和抑郁症的结果漏斗图

Figure 3. The funnel plot of eczema and depression outcomes

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图 4 留一法敏感性分析结果

Figure 4. Leave-one-out sensitivity analysis results

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表 1 样本基本信息

Table 1. Sample basic information

暴露/结局	GWAS号	病例(例)	对照(例)	SNP数量	人群	年份
湿疹	ieu-a-996	10 788	30 047	11 059 641	European	2014年
抑郁症	ukb-d-20544_11	25 087	92 695	13 571 547	European	2018年
注：SNP为单核苷酸多态性(single nucleotide polymorphism)。

下载: 导出CSV

表 2 孟德尔随机化分析结果

Table 2. Results of mendelian randomization analysis

方法	效应值	P值	OR值	OR_lci95	OR_uci95
MR Egger	0.010	0.529	1.010	0.980	1.041
Weighted median	0.012	0.029	1.012	1.001	1.023
Inverse variance weighted	0.011	0.037	1.011	1.001	1.022
Simple mode	0.013	0.147	1.013	0.997	1.029
Weighted mode	0.011	0.141	1.012	0.997	1.026

下载: 导出CSV

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