Habilitation护理模式对糖尿病脑病患者血糖控制及认知功能的影响

王雪; 董兵轮; 芦阳; 刘羽; 赵鑫

doi:10.16766/j.cnki.issn.1674-4152.003859

Habilitation护理模式对糖尿病脑病患者血糖控制及认知功能的影响

doi: 10.16766/j.cnki.issn.1674-4152.003859

王雪^1, ,,
董兵轮²,
芦阳²,
刘羽³,
赵鑫¹

1.
秦皇岛市中医医院脑病科，河北秦皇岛 066000
2.
秦皇岛市中医医院药剂科
3.
秦皇岛市中医医院脾胃科

基金项目:

河北省中医药管理局科研计划项目 2024420

详细信息

通讯作者:
王雪，E-mail：1209261503@qq.com

中图分类号: R473.74 R742
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- 文章访问数: 29
- HTML全文浏览量: 18
- PDF下载量: 1
- 被引次数: 0
出版历程
- 收稿日期: 2024-04-21
- 网络出版日期: 2025-02-13

Effects of Habilitation nursing model on glycemic control and cognitive function in patients with diabetic encephalopathy

WANG Xue^{1
, ,},
DONG Binglun²,
LU Yang²,
LIU Yu³,
ZHAO Xin¹

1.
Department of Neurology, Qinhuangdao Hospital of Traditional Chinese Medicine, Qinhuangdao, Hebei 066000, China

摘要

摘要: 目的探讨Habilitation护理模式在糖尿病脑病(DE)中的护理效果，以及对患者血糖控制及认知功能的影响。方法 2021年1月—2023年6月期间，于秦皇岛市中医医院选取(整群抽样法)398例DE患者，并采用随机数表法分为2组，观察组接受Habilitation护理模式干预(200例)，对照组接受常规护理(198例)，对比相关指标。结果经Habilitation护理模式干预后，观察组餐后2 h血糖[2hPG，(9.28±0.51)mmol/L vs. (9.97±2.11)mmol/L]、餐后血糖波动值[PPGE，(2.28±0.51)mmol/L vs. (2.54±0.45)mmol/L]和血清糖化血红蛋白A1c[HbA1c，(6.27±0.63)% vs. (6.49±1.26)%]、白细胞介素-6(IL-6)、神经元特异性烯醇化酶(NSE)浓度均低于对照组，超氧化物歧化酶(SOD)浓度、丙二醛(MDA)和生活质量综合评定问卷(GQOL-74)总分均高于对照组，差异均有统计学意义(P＜0.05)。结论 Habilitation护理模式能够有效改善血糖控制情况，提升DE患者的认知功能，减少机体炎症、减轻神经损伤。
- 糖尿病脑病 /
- Habilitation护理模式 /
- 血糖控制 /
- 认知功能 /
- 炎症 /
- 神经损伤
Abstract: Objective To investigate the efficacy of Habilitation nursing model in patients with diabetic encephalopathy (DE) and its influence on glycemic control and cognitive function. Methods From January 2021 to June 2023, a total of 398 patients with DE were selected from Qinhuangdao Hospital of Traditional Chinese Medicine (cluster sampling method) and were divided into two groups by random number table method: the observation group (200 patients), which received Habilitation nursing intervention or the control group (198 patients), which received conventional nursing. Relevant clinical indicators were compared between the two groups. Results After the intervention, the observation group showed significantly lower levels of 2-hour postprandial glucose [2hPG, (9.28±0.51) mmol/L vs. (9.97±2.11) mmol/L], postprandial glucose excursion [PPGE, (2.28±0.51) mmol/L vs. (2.54±0.45) mmol/L], serum glycosylated hemoglobin A1c [HbA1c, (6.27±0.63)% vs. (6.49±1.26)%], interleukin-6 (IL-6), and neuron-specific enolase (NSE) compared to the control group. The levels of superoxide dismutase (SOD), malondialdehyde (MDA), and scores on the generic quality of life inventory (GQOL-74) were higher than those in the control group, with statistically significant differences (P < 0.05). Conclusion The Habilitation nursing model effectively improves glycemic control, enhances cognitive function, reduces inflammation, and alleviates nerve damage in DE patients.
- Diabetic encephalopathy /
- Habilitation nursing mode /
- Glycemic control /
- Cognitive function /
- Inflammation /
- Nerve damage

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表 1 2组糖尿病脑病患者一般资料比较

Table 1. Comparison of general data between two groups of patients with diabetic encephalopathy

组别	例数	性别(例)		年龄 (x±s，岁)	糖尿病病程 (x±s，年)	BMI (x±s)	高血脂病史 (例)	高血压病史(例)	平均动脉压 (x±s，mmHg)
组别	例数	男性	女性	年龄 (x±s，岁)	糖尿病病程 (x±s，年)	BMI (x±s)	高血脂病史 (例)	高血压病史(例)	平均动脉压 (x±s，mmHg)
观察组	200	95	105	58.30±13.51	4.60±1.19	22.06±1.60	105	69	120.05±13.04
对照组	198	113	85	60.15±10.27	4.73±0.85	21.86±1.92	92	87	118.60±9.57
统计量		3.653^a		1.537^b	1.253^b	1.129^b	1.450^a	3.720^a	1.264^b
P值		0.056		0.125	0.211	0.259	0.229	0.054	0.207
注：^a为χ²值，^b为t值。1 mmHg=0.133 kPa。

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表 2 2组糖尿病脑病患者血糖指标比较(x±s)

Table 2. Comparison of blood glucose levels between two groups of patients with diabetic encephalopathy(x±s)

组别	例数	FBG(mmol/L)		HbA1c(%)		2hPG(mmol/L)		HbA1c(%)
组别	例数	干预前	干预后	干预前	干预后	干预前	干预后	干预前	干预后
观察组	200	9.05±0.56	7.41±0.40^b	8.31±1.20	6.27±0.63^b	15.46±0.97	9.28±0.51^b	5.02±1.02	2.28±0.51^b
对照组	198	9.17±0.87	7.50±0.63^b	8.42±0.71	6.49±1.26^b	15.32±0.43	9.97±2.11^b	5.17±0.89	2.54±0.45^b
统计量		1.638^a	1 223.042^c	1.112^a	1 500.351^c	1.858^a	956.014^c	1.563^a	1 551.202^c
P值		0.102	< 0.001	0.267	< 0.001	0.064	< 0.001	0.119	< 0.001
注：^a为t值，^c为F值；与同组干预前比较，^bP＜0.05。

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表 3 2组糖尿病脑病患者干预前后MoCA评分比较(x±s，分)

Table 3. Comparison of MoCA scores before and after intervention between two groups of patients with diabetic encephalopathy (x±s, points)

组别	例数	视空间技能和执行能力		计算		注意与集中能力		语言
组别	例数	干预前	干预后	干预前	干预后	干预前	干预后	干预前	干预后
观察组	200	4.07±1.13	4.32±0.15^b	2.36±0.76	3.51±1.04^b	3.38±1.09	3.82±0.46^b	2.02±0.51	2.41±0.72^b
对照组	198	3.84±1.23	4.03±0.26^b	2.22±0.70	3.08±0.12^b	3.42±0.45	3.76±0.15^b	2.09±0.30	2.35±0.13^b
统计量		1.943^a	156.014^c	1.911^a	1 554.025^c	0.478^a	1.957^c	1.667^a	2.860^c
P值		0.053	＜0.001	0.057	＜0.001	0.633	0.082	0.096	0.071

组别	例数	抽象思维		记忆		定向力		总分
组别	例数	干预前	干预后	干预前	干预后	干预前	干预后	干预前	干预后
观察组	200	1.61±0.50	2.14±0.03^b	2.74±0.91	3.20±0.77^b	4.45±1.21	4.85±1.20^b	20.63±3.40	24.25±2.93^b
对照组	198	1.66±0.31	1.95±0.49^b	2.57±0.82	3.09±0.41^b	4.61±0.26	4.72±1.04^b	20.41±5.11	22.98±1.58^b
统计量		1.198^a	123.045^c	1.957^a	1.826^c	1.820^a	1.564^c	0.506^a	5.374^c
P值		0.232	＜0.001	0.051	0.056	0.070	0.098	0.263	＜0.001
注：^a为t值，^c为F值；与同组干预前比较，^bP＜0.05。

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表 4 2组糖尿病脑病患者干预前后实验室指标比较(x±s)

Table 4. Comparison of laboratory indices before and after intervention between two groups of diabetic encephalopathy patients (x±s)

组别	例数	IL-1β(pg/mL)		IL-6(pg/mL)		NSE(ng/mL)		SOD(U/mg)		MDA(μmol/g)
组别	例数	干预前	干预后	干预前	干预后	干预前	干预后	干预前	干预后	干预前	干预后
观察组	200	25.56±4.29	20.5±2.74^b	44.06±9.83	32.16±4.72^b	17.29±2.16	16.67±3.02^b	90.05±11.92	105.62±13.05^b	8.07±0.72	7.05±1.03^b
对照组	198	24.86±2.83	21.01±3.03^b	42.75±12.62	33.48±5.89^b	17.61±4.04	18.07±2.91^b	92.19±9.88	102.72±9.11^b	8.15±1.03	6.91±0.17^b
统计量		1.919^a	4.366^c	1.156^a	1 124.117^c	0.987^a	893.447^c	1.949^a	1 110.654^c	0.899^a	5.690^c
P值		0.056	0.092	0.248	0.014	0.324	＜0.001	0.052	0.011	0.369	0.087
注：^a为t值，^c为F值；与同组干预前比较，^bP＜0.05。

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表 5 2组糖尿病脑病患者干预前后GQOL-74得分比较(x±s，分)

Table 5. Comparison of GQOL-74 scores before and after intervention between two groups of diabetic encephalopathy patients (x±s, points)

组别	例数	社会社交情况		生活质量状况		心理功能		躯体功能		总分
组别	例数	干预前	干预后	干预前	干预后	干预前	干预后	干预前	干预后	干预前	干预后
观察组	200	62.43±9.01	78.00±12.42^b	63.01±10.07	70.87±19.62^b	60.01±9.22	75.56±4.88^b	60.08±11.02	75.36±1.27^b	245.53±81.08	299.79±31.25^b
对照组	198	64.02±11.29	69.76±9.72^b	61.57±5.43	66.22±11.07^b	60.32±18.53	73.03±15.40^b	61.24±7.83	70.36±15.55^b	247.15±43.99	279.37±50.24^b
统计量		1.554^a	156.972^c	1.773^a	779.345^c	0.212^a	1 106.870^c	1.209^a	700.681^c	0.247^a	978.113^c
P值		0.121	＜0.001	0.077	＜0.001	0.833	＜0.001	0.227	＜0.001	0.805	＜0.001
注：^a为t值，^c为F值；与同组干预前比较，^bP＜0.05。

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