血清蛋白激酶C<i>ε</i>活性及心肌损伤标志物与急性胸痛患者心肌梗死发生的相关性分析

郝翠君; 王蕊; 洪洋; 李晓颖; 韩少洁; 李方江

doi:10.16766/j.cnki.issn.1674-4152.004034

血清蛋白激酶Cε活性及心肌损伤标志物与急性胸痛患者心肌梗死发生的相关性分析

doi: 10.16766/j.cnki.issn.1674-4152.004034

1.
河北北方学院附属第一医院心血管内科，河北张家口 075000
2.
河北北方学院附属第一医院检验科

基金项目:

河北省2024年度医学科学研究课题计划 20242070

河北省2020年度医学科学研究课题计划 20200509

详细信息

通讯作者:
王蕊，E-mail：xinneikewr@163.com

中图分类号: R542.22
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- 被引次数: 0
出版历程
- 收稿日期: 2024-10-16
- 网络出版日期: 2025-09-04

The correlation between serum protein kinase Cε activity, myocardial injury markers and myocardial infarction in patients with acute chest pain

1.
Department of Cardiovascular Medicine, the First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei 075000, China

摘要

摘要: 目的探究血清蛋白激酶Cε(PKCε)活性及心肌损伤标志物与急性胸痛患者心肌梗死(AMI)发生的相关性，为临床急性胸痛患者AMI防治提供参考。方法选择河北北方学院附属第一医院2022年3月—2024年3月收治的268例急性胸痛患者，按AMI有无发生分为AMI组(145例)与非AMI组(123例)进行比较分析，以评估血清PKCε活性及心肌损伤标志物[肌红蛋白(Mb)、心肌肌钙蛋白Ⅰ(cTnI)及肌酸激酶同工酶(CK-MB)]的临床价值。结果 AMI组血清PKCε水平[(60.31±11.24)μg/L]低于非AMI组[(87.25±15.96)μg/L]，Mb、cTnI及CK-MB水平[(119.85±24.72)μg/L、(1.58±0.30)ng/mL、(33.47±8.19)U/L]高于非AMI组[(90.69±18.41)μg/L、(0.91±0.15)ng/mL、(15.36±3.79)U/L]，差异均有统计学意义(t=16.148、10.788、22.494、22.556，均P＜0.05)。Spearman相关性分析显示，PKCε与急性胸痛患者AMI发生呈负相关关系，Mb、cTnI及CK-MB与急性胸痛患者AMI发生呈正相关关系(r=-0.762、0.611、0.841、0.799，P＜0.05)。结论血清PKCε活性及心肌损伤标志物与急性胸痛患者AMI发生密切相关，可在一定程度上评估急性胸痛患者AMI的发生情况。
- 急性心肌梗死 /
- 胸痛 /
- 蛋白激酶Cε /
- 心肌损伤标志物
Abstract: Objective To explore the correlation between serum protein kinase Cε (PKCε) activity, myocardial injury markers and acute myocardial infarction (AMI) in patients with acute chest pain. The study will provide a reference for the prevention and treatment of AMI in patients with acute chest pain. Methods A total of 268 patients with acute chest pain who were admitted to the First Affiliated Hospital of Hebei North University from March 2022 to March 2024 were selected and divided into two groups: the AMI group and the non-AMI group according to the occurrence of AMI. Serum PKCε activity and levels of myocardial injury markers [myoglobin (MB), cardiac troponin Ⅰ (cTnI) and creatine kinase-MB (CK-MB)] were evaluated. Results The present study found that the AMI group exhibited a lower level of PKCε [(60.31±11.24) μg/L] in comparison to the control group [(87.25±15.96) μg/L]. Furthermore, the AMI group demonstrated higher levels of Mb, cTnI and CK-MB [(119.85±24.72) μg/L, (1.58±0.30) ng/mL and (33.47±8.19) U/L], with the concentrations of (90.69±18.41) μg/L, (0.91±0.15) ng/mL and (15.36±3.79) U/L being found to be significantly higher (t=16.148, 10.788, 22.494, 22.556, P < 0.05). Spearman correlation analysis demonstrated a negative correlation between PKCε and AMI occurrence in patients with acute chest pain, while Mb, cTnI and CK-MB exhibited a positive correlation with this outcome (r=-0.762, 0.611, 0.841, 0.799, P < 0.05). Conclusion Serum PKCε activity and myocardial injury markers have been demonstrated to be closely related to AMI occurrence in patients with acute chest pain, and they which can therefore serve as a means to evaluate AMI occurrence in this patient group to a certain extent.
- Acute myocardial infarction /
- Chest pain /
- Protein kinase Cε /
- Markers of myocardial injury

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表 1 2组急性胸痛患者基线资料比较

Table 1. Comparison of baseline data between the two groups of patients with acute chest pain

组别	例数	性别[例(%)]		年龄 (x±s，岁)	基础疾病[例(%)]
组别	例数	男性	女性	年龄 (x±s，岁)	高血脂	高血压	糖尿病
AMI组	145	99(68.28)	46(31.72)	52.75±4.38	83(57.24)	102(70.34)	38(26.21)
非AMI组	123	78(63.41)	45(36.59)	53.26±4.71	57(46.34)	85(69.11)	34(27.64)
统计量		0.701^a		0.918^b	3.169^a	0.048^a	0.070^a
P值		0.402		0.360	0.075	0.826	0.792
注：^a为χ²值，^b为t值。

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表 2 2组急性胸痛患者PKCε及心肌损伤标志物水平比较(x±s)

Table 2. Comparison of PKCε and myocardial injury markers between the two groups of patients with acute chest pain (x±s)

组别	例数	PKCε (μg/L)	Mb (μg/L)	cTnI (ng/mL)	CK-MB (U/L)
AMI组	145	60.31±11.24	119.85±24.72	1.58±0.30	33.47±8.19
非AMI组	123	87.25±15.96	90.69±18.41	0.91±0.15	15.36±3.79
t值		16.148	10.788	22.494	22.556
P值		＜0.001	＜0.001	＜0.001	＜0.001

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表 3 PKCε及心肌损伤标志物与急性胸痛患者AMI发生的相关性分析

Table 3. Correlation analysis of PKCε and myocardial injury markers with AMI in patients with acute chest pain

项目	r值	P值
PKCε	-0.762	＜0.001
Mb	0.611	＜0.001
cTnI	0.841	＜0.001
CK-MB	0.799	＜0.001

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