生酮饮食在乳腺癌治疗中的作用研究进展

李一鸣; 姚昶; 张紫昊

doi:10.16766/j.cnki.issn.1674-4152.004057

生酮饮食在乳腺癌治疗中的作用研究进展

doi: 10.16766/j.cnki.issn.1674-4152.004057

1.
南京中医药大学附属医院乳腺外科，江苏南京 210029
2.
河南中医药大学第一临床医学院，河南郑州 450000

基金项目:

江苏省中医院高峰学术人才项目 y2021rc09

江苏省基础研究计划自然科学基金项目 BK20221424

详细信息

通讯作者:
姚昶，E-mail：yaochang67@126.com

中图分类号: R737.9
计量
- 文章访问数: 11
- HTML全文浏览量: 9
- PDF下载量: 2
- 被引次数: 0
出版历程
- 收稿日期: 2024-07-12
- 网络出版日期: 2025-09-04

Advances in the study of the role of ketogenic diet in the treatment of breast cancer

1.
Department of Breast Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, China

摘要

摘要: 乳腺癌(BC)的发生与生活方式、自然环境以及饮食密切相关。饮食摄入是影响肿瘤代谢的关键环境因素，不良的饮食习惯会增加乳腺癌的发病风险，而健康的饮食则有助于减少慢性炎症及其对DNA的损伤，从而对人体健康产生积极影响。饮食干预作为一种乳腺癌辅助治疗方法受到广泛关注。在众多饮食干预方法中，生酮饮食(KD)因其在调节代谢、控制疾病发展和减少治疗不良反应方面的潜力，成为研究热点。生酮饮食主要由高脂肪、中等蛋白质和极低碳水化合物组成，通过改变患者的饮食结构生成内源性酮体，使身体从葡萄糖依赖性能量状态转变为依赖脂肪的能量状态，并降低胰岛素水平，直接或间接影响癌细胞的能量代谢、提高靶向药的治疗效果、减少癌细胞的增殖并改善细胞的程序性死亡等。KD对于调节乳腺癌患者大脑神经功能有着积极影响，有助于改善患者的不良情绪和身体状态，提高生活质量。生酮饮食作为一种新兴的乳腺癌辅助治疗策略，显示出多方面的潜在益处，有望在未来的乳腺癌治疗中发挥重要作用。本文将深入探讨生酮饮食对乳腺癌治疗的多方面影响，包括其在免疫调控、代谢状态、基因表达以及潜在分子机制等方面的作用。通过总结现有研究成果，为乳腺癌的综合治疗提供新的视角和方法，探索KD在未来临床实践中的应用潜力。
- 乳腺癌 /
- 生酮饮食 /
- 研究进展 /
- 辅助治疗
Abstract: The development of breast cancer (BC) is associated with lifestyle, natural environment and diet. Dietary intake is a significant environmental factor impacting tumor metabolism, with unhealthy dietary habits increasing the risk of BC, while a healthy diet can reduce chronic inflammation and DNA damage, thereby positively impacting human health. The potential of dietary intervention as an adjuvant therapy for breast cancer has garnered considerable attention. Among various dietary intervention methods, the ketogenic diet (KD) has become a research hotspot due to its potential in regulating metabolism, controlling disease progression, and reducing adverse treatment reactions. The KD is characterized by a high fat, medium protein, and extremely low carbohydrate composition. By modifying the patient ' s dietary structure, endogenous ketone bodies are generated, thereby transforming the body from a glucose dependent energy state to a fat dependent energy state and reducing insulin levels. This directly or indirectly affects the energy metabolism of cancer cells, improves the therapeutic effect of targeted drugs, reduces cancer cell proliferation, and improves programmed cell death. KD has been shown to positively impact brain nerve function in breast cancer patients, contributing to an improvement in mood and physical well-being, and enhancing the quality of life. The ketogenic diet, in its capacity as a novel adjuvant treatment strategy for breast cancer, has been shown to possess numerous potential benefits and is anticipated to assume an important role in the treatment of breast cancer in the future. This article will explore the effects of KD on the treatment of breast cancer from multiple perspectives, including its role in immune regulation, metabolic status, gene expression and potential molecular mechanisms. By synthesizing the extant research findings, this study offers a novel perspective and methodology for the comprehensive management of breast cancer and investigates the potential of KD to be integrated into future clinical practice.
- Breast cancer /
- Ketogenic diet /
- Research progress /
- Complementary therapy

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