中枢和周围神经系统联合脱髓鞘疾病3例并文献复习

吴文静; 陈蓉

doi:10.16766/j.cnki.issn.1674-4152.004069

中枢和周围神经系统联合脱髓鞘疾病3例并文献复习

doi: 10.16766/j.cnki.issn.1674-4152.004069

吴文静,
陈蓉^,

海南医科大学第一附属医院神经内科，海南海口 570100

基金项目:

海南省自然科学基金高层次人才项目 2019RC379

详细信息

通讯作者:
陈蓉，E-mail：13876901909@126.com

中图分类号: R744.5
计量
- 文章访问数: 11
- HTML全文浏览量: 13
- PDF下载量: 2
- 被引次数: 0
出版历程
- 收稿日期: 2024-07-10
- 网络出版日期: 2025-09-04

Combined central and peripheral demyelination: three case reports and literature review

WU Wenjing,
CHEN Rong^,

Department of Neurology, the First Affiliated Hospital of Hainan Medical College, Haikou, Hainan 570100, China

摘要

摘要: 中枢和周围神经系统联合脱髓鞘疾病是一种罕见的神经系统疾病，其特点是外周和中枢联合脱髓鞘现象。该病发病机制尚未明确，临床诊治相对困难且相关报道较少。本文通过对海南医科大学第一附属医院神经内科诊治的3例中枢和周围神经系统联合脱髓鞘患者进行总结与分析，包括其临床特点、影像学特点和肌电图特点，旨在提高临床医生对该病的认知并减少漏诊。
- 中枢和周围神经系统联合脱髓鞘疾病 /
- 临床特点 /
- 发病机制
Abstract: The combined central and peripheral demyelination is a rare neurological disorder characterized by combined demyelination in the central and peripheral nervous system. The pathogenesis of this disease is not clear, and clinical diagnosis and treatment are relatively difficult and there are fewer reports on it. In this paper, we reviewed and analyzed the clinical, imaging, and electrophysiological features of three cases of combined central and peripheral demyelination reported by the Department of Neurology, the First Affiliated Hospital of Hainan Medical University, in order to raise the awareness of clinicians and reduce misdiagnosis.
- Combined central and peripheral demyelination /
- Clinical characteristics /
- Pathogenesis

HTML全文

图 1 病例1颅脑及颈髓MRI结果

注：A为颈髓增强C₄~T₁椎体水平脊髓异常信号；B、C、D为磁共振颅脑平扫及增强可见双侧三脑室周围白质、半卵圆中心区、放射冠、右侧小脑半球多发斑片状异常信号高密度影。

Figure 1. MRI results of cranial brain and cervical spinal cord in case 1

下载: 全尺寸图片幻灯片

图 2 病例2颅脑及颈髓MRI结果

注：A为颈髓增强可见延髓内及C_2~3水平脊髓内多发病灶；B为磁共振颅脑平扫及增强可见延髓斑片状异常信号改变；C为DWI未见明显弥散受限。

Figure 2. MRI results of cranial brain and cervical spinal cord in case 2

下载: 全尺寸图片幻灯片

图 3 病例3颈髓MRI结果

注：A为2017年1月9日颈段脊髓MRI示C₁~T₁₀椎体水平长条状高密度影；B为2018年1月18日颈段脊髓MRI未见明显异常；C为2018年5月28日颈段脊髓MRI示C₂~T₁₀椎体水平长条状高密度影；D为2019年6月10日颈段脊髓MRI未见明显异常。

Figure 3. MRI results of cervical spinal cord in case 3

下载: 全尺寸图片幻灯片

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