中医药调节肿瘤微环境研究文献的可视化分析

董慧静; 郑玉敏; 李嘉; 鲁星妤; 崔慧娟

doi:10.16766/j.cnki.issn.1674-4152.004228

中医药调节肿瘤微环境研究文献的可视化分析

doi: 10.16766/j.cnki.issn.1674-4152.004228

1.
北京中医药大学中日友好临床医学院, 北京 100029
2.
中日友好医院中西医结合肿瘤内科, 北京 100029

基金项目:

中日友好医院高水平医院临床业务费资助项目 2022-NHLHCRF-LX-02-0111

首都卫生发展科研专项项目 2022-2-4065

详细信息

通讯作者:
崔慧娟, E-mail: chjzryhyy@sina.com

中图分类号: R273 R730.231
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出版历程
- 收稿日期: 2024-09-18

Visualization analysis of research literature on TCM regulation of tumor microenvironment

1.
Beijing University of Chinese Medicine, China-Japan Friendship Clinical Medical College, Beijing 100029, China

摘要

摘要: 目的肿瘤微环境是肿瘤领域的重点问题。本研究通过可视化方法系统分析中医药调节肿瘤微环境的研究现状和热点，旨在揭示其主要机制和临床应用。方法在中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(VIP)、中国生物医学文献数据库(CBM)、Web of Science(WOS)分别进行文献检索，时间设置为建库至2024年3月22日。应用NoteExpress进行文献筛选，使用GraphPad Prism绘制每年发文量计量分析图；采用VOSviewer对作者、关键词进行分析，绘制作者共现网络、关键词时间网络；利用CiteSpace进行关键词聚类分析。结果最终纳入690篇文献。首篇研究自2005年出现，2018年后发文量呈现快速上升趋势。发文量较多的期刊有《中华中医药杂志》《中医杂志》《中国实验方剂学杂志》《Journal of Ethnopharmacology》《Fronyiers in Pharmacology》等。中文文章共涉及作者1 766人。英文文章共涉及作者1 443人。得到中文关键词聚类9个、英文关键词聚类11个，主要包括作用机制和临床应用领域。结论通过可视化分析，研究发现中医药通过影响肿瘤血管生成、炎症、外泌体、细胞自噬与凋亡、巨噬细胞极化等机制调控肿瘤微环境，目前广泛应用于乳腺癌、肺癌、肝癌、结直肠癌、胃癌等癌种。
- 中医药 /
- 肿瘤微环境 /
- 可视化分析 /
- 文献计量学 /
- VOSviewer /
- CiteSpace软件
Abstract: Objective The tumor microenvironment has been a critical focus in cancer research. This study employs visualization methods to systematically analyze the current research landscape and highlight key areas of interest concerning the regulation of the tumor microenvironment by traditional Chinese medicine. The objective is to elucidate its primary mechanisms and clinical applications. Methods A comprehensive literature search was conducted across various databases including CNKI, Wanfang Data, VIP, CBM, and WOS, with the search period ending on March 22, 2024. NoteExpress was used for literature screening, GraphPad Prism was employed to chart annual publication trends, VOSviewer was used for analyzing authors and keywords and creating author co-occurrence networks and keyword time networks, and CiteSpace was used for keyword clustering analysis. Results A total of 690 documents were included in the study. The earliest publication was recorded in 2005, with a significant increase in publications observed since 2018. High-frequency publishing journals include 'China Journal of Traditional Chinese Medicine and Pharmacy', 'Journal of Traditional Chinese Medicine', 'Chinese Journal of Experimental Traditional Medical Formulas', 'Journal of Ethnopharmacology', and 'Fronyiers in Pharmacology'. The Chinese-language publications included a total of 1 766 authors, while English-language publication included a total of 1 443 authors. A total of 9 Chinese and 11 English keyword clusters were identified, with major themes centering on mechanisms of action and clinical applications. Conclusion Visual analysis found that TCM regulates the tumor microenvironment by pathways including tumor angiogenesis, inflammation, exosomes, autophagy, apoptosis, and macrophage polarization. TCM has been widely applied in the treatment of various cancer types, including breast, lung, liver, colorectal, and gastric cancers.
- Traditional Chinese medicine /
- Tumor microenvironment /
- Visual analysis /
- Bibliometrics /
- VOSviewer /
- CiteSpace
利益冲突 无

HTML全文

图 1 2005—2024年中医药调节肿瘤微环境研究文献发文量分布

Figure 1. The distribution of research literature on the regulation of tumor microenvironment by traditional Chinese medicine from 2005 to 2024

下载: 全尺寸图片幻灯片

图 2 中、英文文献关键词聚类(颜色表示聚类，数字标签越小则包含关键词越多)

Figure 2. Cluster analysis of keywords in Chinese and English literature (Colors represent distinct clusters, and the cluster number is inversely proportional to the number of keywords it contains)

下载: 全尺寸图片幻灯片

图 3 中、英文高频关键词共现时间网络

Figure 3. Evolution of keyword co-occurrence networks in Chinese and English literature

下载: 全尺寸图片幻灯片

表 1 中医药调节肿瘤微环境相关中文文献来源期刊(≥10篇)

Table 1. Chinese literature search strategy on the regulation of the tumor microenvironment by traditional Chinese medicine (retrieved ≥10 relevant articles)

来源期刊	发表数量(%)
中华中医药杂志	31(6.62)
中医杂志	23(4.91)
中国实验方剂学杂志	22(4.70)
时珍国医国药	12(2.56)
中国中医基础医学杂志	11(2.35)
世界中医药	10(2.14)

下载: 导出CSV

表 2 中医药调节肿瘤微环境相关英文文献来源期刊(≥5篇)

Table 2. English literature search strategy on traditional Chinese medicine regulation of the tumor microenvironment (yielding ≥5 relevant articles)

来源期刊	发表数量(%)
Journal of Ethnopharmacology	21(9.46)
Frontiers in Pharmacology	18(8.11)
Evidence-based Complementary and Alternative Medicine	12(5.41)
Phytomedicine	10(4.50)
Chinese Journal of Integrative Medicine	9(4.05)

下载: 导出CSV

表 3 中英文文献高频关键词(前15位)

Table 3. Most frequent keywords in Chinese and English literature (Top 15)

关键词	共现次数	关键词	共现次数
肿瘤微环境	190	tumor microenvironment	47
肿瘤	59	expression	42
微环境	38	cancer	41
中医药	34	cells	41
乳腺癌	32	apoptosis	33
肝癌	27	Traditional Chinese Medicine	33
免疫微环境	23	metastasis	25
肺癌	23	activation	22
胃癌	21	growth	20
肿瘤相关巨噬细胞	19	inflammation	20
结直肠癌	17	colorectal cancer	19
肿瘤免疫微环境	14	macrophages	18
小鼠	13	therapy	17
癌毒	13	epithelial-mesenchymal transition	14
网络药理学	13	proliferation	14

下载: 导出CSV

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