Abstract: Objective To analyze the application of sevoflurane,propofol and fentanyl in tonsillectomy of children. Methods Forty ASA children undergoing elective tonsillectomy were selected,and randomly divided into two groups:the control group received ketamine,propofol and fentanyl(n=20),the observation group received sevoflurane,propofol and fentanyl(n=20).The anesthesia induction completion time,induced compliance score,intraoperative mean arterial pressure(MAP),heart rate(HR),pulse oxygen saturation(SPO₂),respiratory frequency(RR) were compared.The time of extubation and wake-up,incidence of agitation and incidence of nausea and vomiting were noted after operation. Results Patients exhibited lower MAP,HR,RR during induction of anesthesia in the observation group than in the control group(P＜0.05).The induced compliance score in the observation group was better than in the control group(P＜0.05).The incidence of agitation and incidence of nausea and vomiting were lower in the observation group than in the control group(P＜0.05).The spontaneous breathing recovery time,consciousness recovery time,and extubation time of the observation group was lower than the control group(P＜0.05). Conclusion In tonsillectomy of children,sevoflurane,propofol and fentanyl has high safety,less side effect,and to some extent,shortens the children wake up time.