Abstract: Objective To study the change of serum lipoprotein(a)[Lp(a)]of wounded-bone patient and its clinical significance. Methods Total 2 500 cases of wounded-bone patients in our hospital were assigned into observation group;200 physical examinees were selected as control group.The levels of serum Lp(a) and lipid index,myocardial index of the two groups were detected,and the dynamic change between wounded patients and the healthy subjects was compared.The relationship between Lp(a) and lipid index,myocardial index were analyzed. Results Serum Lp(a)levels of 10.0% healthy subjects(20 cases) were more than 300 mg/L.Among the wounded-bone patients,when they were wounded after 24 h,72 h,1 week and 1 month,there were 32.4%,34.0%,35.2%,17.0% patients Lp(a)levels more than 300 mg/L.Serum Lp(a)levels of wounded-bone patients were higher than those of healthy subjects when the patients were wounded after 24 h,72 h and 1 week(P＜0.05).When the patients were wounded after 1 month,serum Lp(a) levels of patients were same with the healthy subjects(P＞0.05).There was no significant difference between the two groups in lipid index,myocardial index.Regression analysis showed that there was no correlation between Lp(a) and lipid index,myocardial index in wounded-bone patients. Conclusion Serum Lp(a) levels of wounded patients are remarkably higher than those in healthy subjects;the Lp(a) level increases is independent of cardiovascular disease;the increase of Lp(a)levels in wounded-bone patients could be associated with wounded stress.