Abstract: Objective To investigate the status of TORCH infection in pregnant women and newborn and its relationship with abnormal pregnancy and neonatal common diseases in Nanning area. Methods TORCH antibody was detected by using enzyme linked immunosorbent assay method in the serum form 39 281 pregnant women,4 833 cord blood and 18 757 newborn from January 2008 to December 2013.The clinical diagnostic information was collected and analyzed.The positive of TORCH in abnormal pregnancy group,normal pregnancy group and infants with different diseases were compared. Results The positive rate of TORCH-IgM was 2.86%,0.89% and 1.60% in 39 281 pregnant women,4 833 cord blood and 18 757 newborns,respectively.And the rate of CMV-IgM was higher than other pathogen in those three groups(0.88%,0.34% and 1.31%,respectively).The positive rate of TORCH-IgM in normal group and abnormal group were 1.44% and 0.45%,respectively(P＜0.05),and was 18.70%,2.74%,1.93% and 1.64% in newborn with hepatitis syndrome,pathological jaundice,septicemia and pneumonia,respectively. Conclusion CMV was the main pathogen of infection in pregnant women and newborn,and were associated with hepatitis syndrome and pathological jaundice.It is necessary to take the screening for TORCH in this area.