Efficacy analysis of traditional Chinese medicine decoction in treatment of recurrent oral ulcer
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摘要: 目的 探讨杭州师范大学附属医院自拟中药汤剂辅助西医常规治疗复发性口腔溃疡的临床疗效和安全性。 方法 将2011年1月—2013年12月间杭州师范大学附属医院口腔科收治的154例复发性口腔溃疡患者按随机数字表法随机分为观察组和对照组,每组患者77例。对照组患者给予常规西医治疗,观察组患者在此基础上加服该院自拟的中药汤剂。治疗1个月,对2组疗效、溃疡愈合时间、疼痛时间、疼痛指数和不良反应进行观察。所有数据均使用SPSS 18.0统计软件进行统计学分析。 结果 观察组近、远期总有效率为分别为97.4%、85.7%,显著高于对照组的85.7%、67.5%,差异具有统计学意义(P<0.05);观察组溃疡愈合时间、溃疡疼痛持续时间、溃疡疼痛指数分别为(4.45±1.8)d、(3.1±1.3)d、(12.3±4.8)分,均显著低于对照组的(7.09±2.3)d、(5.4±1.7)d、(25.1±6.9)分,差异具有统计学意义(P<0.05);2组不良反应率比较,差异无统计学意义(P>0.05)。 结论 在西医常规治疗复发性口腔溃疡基础上,加服该院自拟的中药汤剂可明显缩短病程、缓解疼痛、提高疗效。Abstract: Objective To investigate the clinical efficacy and safety of Chinese medicinal herb soup assisted with routine western medicine in the treatment of recurrent oral ulceration(ROU). Methods Total 154 cases of recurrent oral ulcer in our department from January 2011 to December 2013 were randomly divided into observation group and control group,each group 77 case.The patients in the control group were given conventional western medicine,while the patients in the observation group were added Chinese medicinal herb soup.After one month treatment,the efficacy,healing ulcer time,pain time,pain level and adverse reaction of both groups were observed.All data were analyzed by SPSS 18.0 statistical software. Results The recently and long-term total effective rate of observation group were 97.4% and 85.7%,which were significantly higher than that of control group (85.7% and 67.5%),the differences were statistically significant(P<0.05).The healing ulcer time,pain time,pain level of the observation group were (4.45±1.8)d,(3.1±1.3)d,(12.3±4.8) score,which were significantly higher than that of control group[(7.09±2.3)d,(5.4±1.7)d,(25.1±6.9) score],the differences were statistically significant(P<0.05).There was no significant differences of two groups on adverse reaction rates(P>0.05). Conclusion Based on conventional western medicine,Chinese medicinal herb soup in treatment of recurrent oral ulcer can significantly shorten disease course,relieve pain,and enhance clinical efficacy.
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Key words:
- Recurrent oral ulceration /
- Chinese herb soup /
- Therapeutic efficacy
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