Abstract: Objective To analyze the treatment method of gasless laparoscopic and CO₂ pneumoperitoneum laparoscopic varicocele,compare the of hemodynamic changes and perioperative variations of different methods. Methods The 40 cases of varicocele patients (all the left) were divided into gasless group and CO₂ pneumoperitoneum group according to the order of admission time randomly,and there were 20 patients in each group.All patients were given High-level ligation of spermatic vein;Comparison of per-operative changes were done between gasless group and CO₂ pneumoperitoneum laparoscopic group,including detection of two groups of patients before the start of anesthesia(T1),suspension or gas after the abdomen after the establishment of 30 min(T2) and the suspension or removal of pneumoperitoneum 10 min(T3) and mean arterial pressure of three time-point,central venous pressure,heart rate,oxygen saturation,PH value, arterial pressure of CO₂(PaCO₂) level,and post-operative changes. Results Surgery of 40 patients were successful,the time of bowel function recovery,the incidence of nausea and vomiting between the two groups were statistically significant differences(P＜0.05),and the central venous pressure in the experimental group,PaCO₂ levels were points in time T2 the difference were statistically significant differences (P＜0.05). Conclusions Gasless laparoscopic technique is a safe and feasible method for treatment of varicocele,and easy to maintain stabilization of patient’s vital signs during operative time,and also have advantages of small incision,quick recovery,scar hidden.CO₂ pneumoperitoneum group was gurgling sound recovery time is longer,higher incidence of nausea and vomiting,no hemodynamics and internal environment of the patient’s blood vessel CO₂ gasless laparoscopic surgery.