Abstract: Objective To investigate the influencing factors of the efficacy on virologic response of the standard antiviral therapy in patients with chronic hepatitis C(CHC) and to provide a reference value for clinical treatment. Methods The data of 97 patients with CHC were analyzed retrospectively.The conditions of hepatitis C virus(HCV) genotypes,HCV RNA,and rs8099917 genotypes in interieukin-28B(IL-28B) gene were determined,respectively.The patients were all given the standard antiviral therapy.The influencing factors of rapid virological response(RVR),early virological response(EVR),end-of-treatment virological response(ETVR) and sustained virological response(SVR) were compared and analyzed,respectively. Results The RVR,EVR,ETVR and SVR rates were significant differences in HCV genotype 1 group and in HCV non-genotype 1 group,in rs8099917 genotype TT group and in rs8099917 genotype GT+GG group,respectively(χ²=9.359,11.440,6.346,8.147,9.938,7.413,4.564,4.229;P＜0.05).The independent impact factors of RVR were HCV non-genotype 1,high levels of ALT and AST,low HCV RNA level,and rs8099917 genotype TT;of EVR were HCV non-genotype 1 and low HCV RNA level;of ETVR was high ALT level;and of SVR were HCV non-genotype 1,high ALT level,and rs8099917 genotype TT. Conclusion HCV non-genotype 1,high ALT level,and rs8099917 genotype TT are important favorable factors for SVR in patients with CHC.