Abstract: Objective To explore the value of brain natriuretic peptide(BNP) combined with central venous pressure(CVP) in evaluating volume and cardiac structure and function in uremic patients with hemofiltration(HF). Methods Thirty-six uremic patients with hemofiltration were enrolled.According to hemofiltration,the patients were divided into 2 groups:B(Before) group and A(After) group.When the cardiac function of uremic patients with hemofiltration was from level Ⅳ to level Ⅲ or level Ⅱ,the volume status of the patients was appropriate.Some laboratory parameters and BNP were detected in all patients.All patients were measured by echocardiography for cardiac structure and function.The CVP of the two groups were measured.The clinical data,laboratory parameters and cardiac ultrasound parameters were compared between B and A group.All data were analyzed with statistical software SPSS 17.0. Results Although the values of BNP in uremic patients were significantly decreased after hemofiltration(t=6.494，P＜0.01),they were still higher than normal.The difference of interventricular septum thickness,left ventricular posterior wall thickness and left ventricular ejection fraction between B and A group were significant(t=2.131-2.591，P=0.037-0.012).The difference of CVP between B group and A group were significant(t=11.589，P＜0.01). Conclusion BNP combined with CVP can accurately evaluate the volume status and cardiac structure and function in uremic patients.The values of BNP in uremic patients were high,and it was related to left ventricular hypertrophy.