Correlation of fractional exhaled nitric oxide with peripheral blood eosinophilis and lung function in asthmatic children
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摘要: 目的 探讨6岁及以上哮喘儿童呼出气一氧化氮(FeNO)水平及其与年龄、外周血嗜酸性粒细胞计数百分数(EOS%)和肺功能FEV1%、FEV1/FVC%的相关性。 方法 选择6岁及以上哮喘患儿共70例,按哮喘是否发作分为哮喘急性发作期及缓解期,以同期同年龄门诊健康查体的正常儿童21例为对照组。均行FeNO、肺功能、血EOS检测。 结果 ①哮喘急性发作期组与缓解期组的FeNO、外周血EOS差异无统计学意义(P>0.05),而两者与正常对照组差异均有统计学意义(P<0.05)。急性发作期组的FEV1%、FEV1/FVC%与缓解期组、正常对照组差异有统计学意义(P<0.05),缓解期组与正常对照组差异无统计学意义(P>0.05)。②相关性分析:FeNO与6岁以上患儿年龄呈正相关(r=0.259,P<0.05)),与外周血嗜酸细胞百分比呈正相关(r=0.151,P<0.05);与FEV1/FVC%呈负相关(r=-0.151,P<0.05);FeNO与FEV1%差异无统计学意义(r=-0.12,P>0.05)。 结论 FeNO结合外周血EOS、气流阻塞评价指标即肺功能FEV1/FVC%,可以反映气道嗜酸性炎症及气道情况,帮助哮喘早期诊断,注意判读FeNO结果应考虑年龄因素。Abstract: Objective To explore the level of fractional exhaled nitric oxide(FeNO) in asthmatic children aged 6 year old and above,and its correlation with age,peripheral blood eosinophilia count(EOS%),FEV1% and FEV1/FVC. Methods A total of 70 asthmatic children(age≥6 years) were enrolled and divided into acute exacerbation group and remission group with 21 healthy children as controls.Lung function,FeNO and EOS were measured for all children. Results ①There was no statistical differences in FeNO and EOS between acute exacerbation group and remission group(P>0.05),and there was significant statistical differences between asthmatic children and healthy children(P<0.05).FEV1% and FEV1/FVC among acute exacerbation group,remission group and control group were different(P<0.05),and FEV1% and FEV1/FVC in the remission group were different from the control group(P>0.05).②FeNO had positive relationship with age(r=0.259,P<0.05) and EOS% (r=0.151,P<0.05),and had negative relationship with FEV1/FVC (r=-0.151,P<0.05),and had no correlation with FEV1/FVC(r=-0.12,P>0.05). Conclusion FeNO can stand for the levels of eosinophilic inflammation.It is helpful for early diagnosis about asthma through FeNO and FEV1/FVC,but age could be taken into account.
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Key words:
- Asthma /
- Fractional exhaled nitric oxide /
- Children /
- Peripheral blood eosinophilia /
- Lung function
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