Abstract: Objective To study the effect of post discharge nursing intervention on the nursing quality and quality of life of patients with coronary stent implantation. Methods One hundred and twenty patients with coronary disease undergoing PCI in our hospital between July 2014 and July 2015 were enrolled and randomly assigned into experimental group and control group with 60 cases in each group.The experimental group received the strengthened post discharge nursing intervention,including establishing the special nursing intervention management team outside the hospital and providing sustained health education guidance,psychological guidance,medication guidance and dietary guidance;while the control group received the conventional nursing intervention by random access.All patients were followed up for 1 year and were investigated by questionnaire. The gender,average age,medical history,complications,and the incidence rate of target blood vessel formation,re-hospitalization,rate of adverse events,behavior of self-management and nursing satisfaction were compared between the two groups. Results The re-hospitalization rate,myocardial infarction and other adverse events rate in the control group were higher than those in the experimental group,the difference was statistically significant(χ²=16.752,P＜0.05);the post discharge self-nursing ability scores in each dimension were lower in the control group than those in the experimental group,the difference was statistically significant(t=7.974,P＜0.05);the total nursing satisfaction rate in the control group was 86.21%,which was significantly lower than 98.31% in the experimental group,the difference was statistically significant(χ²=5.926,P＜0.05). Conclusion The method of strengthening post discharge nursing intervention can decrease the risk of adverse cardiac events,improve the subjective activity,post discharge quality of nursing care and quality of life of patients undergoing PCI.It’s worthy to be popularized.