Abstract: Objective To compare the clinical effect and safety of the Mini-TLIF using quadrant minimally invasive system or Open-TLIF in patients with lumbar disc herniation,and to find the most appropriate operative treatment of TLIF. Methods We retrospectively reviewed 186 patients with lumbar disc herniation who were treated in ousr hospital from 2011 to 2014.A total of 102 patients underwent Mini-TLIF and 84 underwent Open-TLIF.The clinical outcomes were evaluated by the operation time,length of incision,amount of bleeding and volume of drainage afteroperation.ODI,VAS,modified Macnab criteria and fusion rate between two groups were also compared. Results There were significantly advantage in Mini-TLIF group in length of incision,amount of bleeding and volume of drainage after operation(P<0.05),but no difference in operation time.The VAS score in Mini-TLIF group was significantly better after the operation but no difference in 6 months after the operation.There was no significantly difference between the two groups in ODI,lumbar function and the fusion though the fusion rate in Open-TLIF group was higher than Mini-TLIF. Conclusion Mini-TLIF has obvious advantages in some aspects like less operation trauma,blood less and satisfied short-term effect in the treatment of lumbar disc herniation,which could be a new choice and be further carried out in the clinical work.