Effectiveness of concurrent chemoradiation with Cisplatin or Nedaplatin for locally advanced cervical cancer
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摘要: 目的 观察并探讨顺铂(cisplatin,CDDP)或奈达铂(nedaplatin,NDP)同步放化疗(radiation and chemotherapy,RCT)对中晚期宫颈癌(cervical cancer,CC)的有效性和安全性。 方法 在2013年5月—2014年7月期间对确诊为中晚期CC患者72例给予同期RCT治疗,其中36例接受CDDP化疗(每周40 mg/m2,直至外照结束时停止),共3个月,作为对照组,另外36例采用NDP化疗(每周40 mg/m2,直至外照结束时停止),每周1次,共5周,作为观察组。按照UICC指定的实体瘤客观疗效判定标准评价2组患者近期疗效,并随访1年生存率、1年转移率和1年复发率以及不良反应发生情况。 结果 观察组缓解率为94.4%(34/36),对照组为72.2%(26/36),观察组缓解率明显高于对照组(χ2=6.400,P<0.05);观察组1年生存率、1年转移率和1年复发率分别为91.7%(33/36)、5.6%(2/36)和8.3%(3/36),对照组为86.1%(31/36)、25.0%(9/36)和33.3%(12/36),2组一年生存率相比,差异不具有统计学意义(P>0.05),观察组转移率和复发率均明显低于对照组(χ2=5.258/6.821;P<0.05);观察组Ⅲ~Ⅳ级白细胞降低、血小板减少、恶心呕吐、腹泻发生率明显低于对照组(P<0.05)。 结论 NDP同期RCT治疗中晚期CC具有良好的近期疗效,且不良反应程度和发生率均更低,值得进一步在临床上推广。Abstract: Objective To explore the effect and safty of concurrent chemoradiationwith Cisplatin(CDDP)or Nedaplatin(NDP)in treatment of locally advanced Cervical cancer(CC). Methods Total 72 patients with advanced CC undergoing concurrent chemoradiation in our hospital from May 2013 to July 2014 were selected.36 cases in the observation group were given NDP treatment for 3 months(40 mg/m2 weekly,until the external lighting end),while 36 cases in the control group were given CDDP treatment for 3 months(40 mg/m2 weekly,until the external lighting end),one times a week,total 5 weeks.The effect was evaluated according to the Evaluation Criteria in Solid Tumors(UICC),and 1-year survivl rate,transfer rate,recurrence rate and adverse reactions were followed up. Results The remission rate was 94.4%(34/36)in the observation group,while was 72.2%(26/36)in the control group,the remission rate in the observation group was obviously higher than that of the control group(χ2=6.400,P<0.05);1-year survival rate,transfer rate and recurrence rate in the observation group were 91.7%(33/36),5.6%(2/36)and 8.3%(3/36),while in the control group was 86.1%(31/36),25.0%(9/36)and 33.3%(12/36),1-year transfer rate and recurrence rate in the observation group was obviously better than that in the control group(χ2=5.258/6.821,P<0.05);the incidence of low white blood cell count(Ⅲ-Ⅳ),low platelets,nausea,vomiting and diarrhea in the control group was significantly higher than those in the observation group(P<0.05). Conclusion The concurrent chemoradiationwith Cisplatin(CDDP)or Nedaplatin(NDP)in treatment of locally advanced Cervical cancer(CC)has a good short-term effect,with lower incidence of adverse reactions,worthy of further promotion in clinical practice.
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Key words:
- Cisplatin /
- Nedaplatin /
- Concurrent chemoradiation /
- Advanced cervical cancer
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