Abstract: Objective To investigate the risk factors of rebleeding in patients with acute non-variceal upper gastrointestinal bleeding(ANVUGIB),and the predicting value of Blatchford and Rockall scoring system. Methods Qualified data of 1 417 patients with ANVUGIB admitted to Tongji Hospital between 2008 and 2012 were collected and scored with Blatchford and Rockall scoring system.According to the outcomes,they were divided into two groups,which including improved group and rebleeding group.Univariate analysis and multivariate logistic regression models were used to evaluate the data of patients’ general state,bleeding performance,co-morbidity,complication,endoscopic situation,usage of drugs and predictive value of risk score. Results Univariate analysis showed that there were the statistically significant between age,heart rate,shock index(SI),blood urea nitrogen(BUN) concentration,ratio of co-morbiditiy of heart disease,hepatic disease,tumor spread,shock anemia(P＜0.05),and both of Rockall and Blatchford system have the value on predicting rebleeding(P＜0.05).Multivariate logistic regression showed high SI,co-morbiditiy of hepatic failure or hepatic disease and high Rockall score are the independent risk factors for rebleeding(P＜0.05). Conclusion The patients with high SI,co-morbiditiy of hepatic failure or hepatic disease and high Rockall score are more likely to suffer rebleeding.