Abstract: Objective To study the association of ICAM-1 K469E polymorphism with cerebral infarction in Han nationality in China. Methods All 213 cases of cerebral infarction(CI group)and 224 people in physical examination(control group)in our hospital from July 2009 to October 2013 were enrolled into this study.All the subjects were compatible in nationality,age abd gender.The polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP)was performed to determine the ICAM-1 K469E polymorphism. Results The areas of cerebral infarction was related to ICAM-1 polymorphism:the index in the extensive cerebral infarction group was significantly higher than that in the small cerebellar infarcts group and lacunar cerebral infarction group,the difference was statistical significance(P<0.05);there was no statistical significance between the small cerebellar infarcts group and lacunar cerebral infarction group(P>0.05).For ICAM-1 genotypes,KK in CI group was was significantly more than that in the control group,the differences was statistically significant P<0.05);EE was slightly lower as compared with the control group;there was no statistically significant in the EK genotype between the two groups(P>0.05);for the alleles,K/E in the CI group was much higher when compared with the control group,the difference was statistically significant(P<0.05). Conclusion The morbidity and areas of cerebral infarction in Han nationality was obviously correlated to ICAM-1K 469E polymorphism,E allele may be the importsant gene for the cerebral infarction in Han nationality in China.