Abstract: Objective To observe and explore the effectiveness of Paliperidone combined with sodium valproate on mental disorders aggressive behavior due to brain injury,and to improve the treatment of mental disorders due to brain injury attacks. Methods Total 96 patients with mental disorders aggressive behavior in this hospital since April 2011 to February 2015 were selected and divided into two groups according to the randomization method,with 48 patients in each group.The control group received paliperidone(initial 6 mg/day,plus to 9-12 mg/days after 1 week)treatment,while the observation group received sodium valproate(0.5 g/d,according to the condition of the need to increase to 0.8 g/d,once a day orally)on the basis of the control group.The Clinical Global Impressions scale(CGI)was used to evaluate the efficacy,and the incidence of adverse reactions were recorded,the data was analyzed by SPSS. Results The difference of CGI score before the treatment between the two groups was not statistically significant(P>0.05);2 weeks,4 weeks and 8 weeks after the treatment,the CGI score of the observation group were (3.1±0.8)point,(2.7±0.7)point and (2.0±0.5)point,the control group (3.9±0.7)point,(3.5±0.8)point and (2.8±0.6)point,CGI score in the observation group was significantly lower than that in the control group(P<0.05);the incidence of adverse reactions in the observation group was 12.5%(6/48),while was 10.4%(5/48)in the control group,the difference was not statistically significant(P＞0.05). Conclusion Paliperidone combined with sodium valproate therapy can significantly improve psychiatric symptoms in patients with mental disorders aggressive behavior due to brain injury,the therapy does not increase the inciedence of adverse reaction,and is safe and effective.