Abstract: Objective To explore the clinical therapeutic effect of hematodialysis combined with hemoperfusion in the treatment of severe acute pancreatitis,and provide a reasonable basis for clinical treatment. Methods Thirty cases of severe acute pancreatitis patients in our hospital from May 2013 to October 2014 were selected,they were received hematodialysis combined with hemoperfusion,and observed the changes of vital signs and chemistry during the treatment: heart rate,body temperature,average arterial pressure,APACHE Ⅱ score,oxygen synthetic index and respiratory rate. Results The 27 patients were improved and discharged,3 patients died,the duration of hospital stay and mortality were (14.1±5.5) days and 10%.Using hematodialysis combined with hemoperfusion in the treatment process and process variations of the clinical indices were better before treatment,compared with those before treatment,P<0.05,with statistical significance.The changes of biochemical indexes were better than that before treatment after treatment compared with those before treatment,P<0.05,with statistical significance. Conclusion The hematodialysis combined with hemoperfusion in treatment of severe acute pancreatitis patients can reduce the mortality of patients with severe acute pancreatitis (SAP),which has good clinical therapeutic effect and less complications.It has great significance to clinical improvement and prognosis.