Abstract: Objective To evaluate the clinical efficacy of the combined therapy withesomeprazole,domperidone and hydrotalcid in patients with bile reflux gastritis(BRG)by observing the clinical symptoms and electronic gastroscopy. Methods Total 90 cases of BRG were randomly divided into control group and observation group according to a completely random number table,45 cases in each group.The control group received domperidone and aluminum magnesium treatment,while the observation group received the combined therapy with esomeprazole,domperidone and hydrotalcid.The clinical symptoms,bile reflux and the condition of the gastric mucosa by the gastroscopy were compared between the two groups. Results There was no statistically significant difference in age,gender,disease duration,clinical symptoms and bile regurgitation,etc.between the two groups(P>0.05).After the treatment,the symptom score of both groups were improved significantly as compared with those before the treatment,and the score of the observation group decreased more significantly than the control group(P<0.05).After the treatment,the gastric acid content and gastric acid secretion of the observation group was (85.13±61.64) mg/ml and (1.31±0.27) mmol/h,respectively,which were significantly lower than (136.28±92.36) mg/ml and (2.81±0.54) mmol/h of the control group(P<0.05).After the treatment,gastric mucosal congestion,edema,erosion,lake bile stained mucus cases were significantly improved in both groups,and the degree of improvement in observation group was more obvious as compared with the control group(P<0.05).Gastric congestion,edema,erosion score of observation group was (0.82±0.29),(0.56±0.16) and (0.62±0.15) points,respectively,and of the control group was(1.38±0.32),(1.53±0.18) and (1.36±0.19) points,respectively,the differences were statistically significant(P<0.05). Conclusion The combined therapy with esomeprazole,domperidone and aluminum magnesium carbonate in patients with bile reflux gastritis has a synergistic effect,which will better improve the clinical symptoms and protect the gastric mucosa.