Abstract: Objective To explore the efficacy ofcombining traditional Chinese and western medicine in the treatment of urinary tract infection diseasein female patients,modify the dosage regime and improve the curative efficacy. Methods Total 100 cases of urinary tract infection disease in female senile patients in our hospital were randomly divided into observation group and control group with 50 cases in each group.The control group was received antibiotic treatment according to their drug susceptibility test results,and the observation group was given Traditional Chinese medicine based on the control group.The efficacy,symptoms improved time,CRP and length of stay in the two groups of patients were compared after two weeks treatment. Results The total effective rate in the observation group was 98.0%,significantly higher than that in the control group(80.0%),the difference was statistically significant(Z=3.375,P＜0.01);the relief time of Urinary frequency and urinary pain in observation group were significantly shorter than those of the control group,the difference was statistically significant t=7.203,9.433,P＜0.01);The level of serum CRP reduced obviously when compared with the control group,the difference was statistically significant(t=12.141，P＜0.01);In the observation group after the treatment,the length of stay was (11.7±2.5)days ,significantly less than that in the control group(16.2±2.8) days,the difference was statistically significant(P＜0.05). Conclusion Combining traditional Chinese and western medicine for urinary tract infection diseasein female senile patients had significant effect and less length of stay,and can significantly reduce the serum levels of inflammatory mediators,which is worthy of clinical promotion and research.