Abstract: Objective To study the effectiveness evaluation of statins treatment and therapeutic lifestyle changes for the patients with dyslipidemia. Methods Two hundred and thirty-one patients with dyslipidemia in the community conform to statin therapy,were randomly divided into two groups,112 cases in the intervention group,give TLC combined with statin treatment,119 cases in the control group,only to give the knowledge related to statin therapy and general dyslipidemia education.Before and after the treatment, the TC,TG,LDL-C,HDL-C,G level of the two groups were test and health knowledge questionnaire scores in the intervention group. Results After 3 months of intervention,the TC,TG,LDL-C,G levels of intervention group were lower than before(P＜0.05),but the patients in the control group only TC,LDL-C levels lower than before(P＜0.05),TG,G had no obvious change(P＞0.05),HDL-C of the two groups had no obvious change(P＞0.05)； comparison with TC,TG,LDL-C and G between two groups,the treatment group were lower than the control group(P＜0.05)；health knowledge questionnaire scores were higher than before after intervention(P＜0.001). Conclusion The effect of community comprehensive prevention and treatment on patients with dyslipidemia is more effective,the TLC is the basic measures of treatment of patients with dyslipidemia.