Correlation between CT perfuson parameters and expression of vascular endothelial growth factor in Laryngeal cancer
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摘要: 目的 探讨喉癌CT灌注参数与血管内皮生长因子(VEGF)表达的相关性及其在喉癌临床诊治中的应用价值。 方法 选取经临床活检证实的喉癌病例23例,行术前CT灌注检查并计算各灌注参数(BF、BV、MTT、PS)值,术后取病变组织行病理学检查证实并行免疫组化染色,检测其VEGF积分。应用SPSS 13.0统计软件包分别对喉癌组织和正常肌肉组CT灌注参数以及喉癌组织CT灌注参数和喉癌术后组织血管内皮生长因子积分进行统计学处理,统计分析各CT灌注参数值与VEGF积分的相关性。 结果 喉癌组织和相应区域正常肌肉间各灌注参数BF值、BV值、MTT值及PS值均存在显著性差异,喉癌的灌注参数明显高于正常肌肉(P<0.05)。喉癌的灌注参数的BF值和BV值与其VEGF积分呈正相关(r=0.502,0.327,P<0.05),MTT值与其VEGF积分呈负相关(r=-0.511,P<0.05),而PS值与其VEGF积分无相关性(r=0.275,P>0.05)。 结论 喉癌CT灌注参数BV、BF值与其VEGF积分具有明显的相关性,可以在一定程度上反映肿瘤的血供情况,术前通过CT灌注成像观察其参数值可以明显提高术前喉癌检查的准确性以及对指导临床抗肿瘤血管生成治疗有重要的意义,具有较高的临床应用价值。Abstract: Objective To observe the correlation between the CT perfusion parameters and the expression of vascular endothelial growth factor(VEGF)in lesions of laryngeal cancer. Methods Twenty-three lesions of laryngeal cancer were scanned by spiral CT,and the perfusion parameters were calculated with perfusion functional software.The parameters included blood flow(BF),blood volume(BV),mean transit time(MTT)and permeability surface(PS).Histopathological slides were prepared for the VEGF immunohistochemical staining.Correlation between the CT perfusion parameters and VEGF was studed. Results ①Between benign and malignant lesions of laryngeal cancer with CT perfusion parameters(BF,BV,MTT and PS)was difference.BF of malignant tumor was higher than that of benign lesions(P<0.05).②In laryngeal cancer,BF and BV was positively correlated with VEGF(r=0.502,0.327,P<0.05),MTT and VEGF showed a negative correlation (r=-0.511,P<0.05),there was not correlative between PS and VEGF(r=0.275,P>0.05). Conclusion CT perfusion parameters of laryngeal cancer is correlated with the level of VEGF,which may reflect the expresion of VEGF.The CT perfusion should be helpful to diagnosis and treatment laryngeal cancer.
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