Abstract: Objective To explore the application of hospital-community-family holistic nursing in the rehabilitation of stroke patients,further make full use of hospitals,community and family resources,fully extend and improve the scope and content of continuation rehabilitation care for stroke patients,and look for a more simple,fast,efficient,practical,affordable new path for the rehabilitation of stroke patients. Methods Total 191 stroke in-patients resided in the community streets belong to our hospital were recruited from November 2013 to July 2014 and assigned into experimental group(98 cases)and control group(93 cases).The control group received the routine rehabilitation nursing,while the experimental group received the hospital-community-family holistic nursing provided by community nurses and ward nurses.The ability of daily life(Barthel Index),mental condition(Hamilton Rating Scale for Depression,HRSD),and patient satisfaction for nursing service were survived at discharge and 6 months late. Results The ability of daily life,mental condition and patient satisfaction were improved in both groups(P<0.05),and more obvious in the experimental group undergoing hospital-community-family holistic nursing. Conclusion Hospital-community-home holistic nursing can effectively improve the ability of daily life and mental condition of stroke patients,promote the physical and psychological recovery.