Abstract: Objective To analyze the efficacy of perioperative,intraoperative and postoperative nursing intervention in patients with hypertensive cerebral hemorrhage after minimally invasive evacuation of intracranial hematoma,and observe the neurological deficit score and postoperative complications. Methods Total 96 patients with hypertensive cerebral hemorrhage received minimally invasive evacuation of intracranial hematoma in our hospital between August 2014 and August 2015.They were randomly divided into two groups.48 cases in the control group were given conventional nursing intervention,and 48 cases in the observation group were given perioperative,intraoperative and postoperative targeted nursing intervention.The clinical effect after the treatment,and the neurological function scores before and after the treatment,as well as the incidence of postoperative complications were compared between the two groups and analyzed using SPSS 20.0 software. Results The overall response rate of clinical nursing in the observation group (95.83%) was obviously higher than that (72.92%) in the control group,the difference was statistically significant(χ²=9.5605,P<0.05).The neurological deficit scores in the observation group (12.03±4.73) points was obviously lower than that in the control group (18.65±5.04) points,the difference was statistically significant(t=6.6356,P<0.05).The incidence of postoperative complications such as rehemorrhage,hypostatic pneumonia,constipation and deep venous thrombosis in the observation group (10.42%) was obviously lower than that in the control group(70.83%),the difference was statistically significant(χ²=33.87,P<0.05). Conclusion The perioperative nursing intervention can effectively improve neurological function and clinical outcomes,reduce complications,promote the recovery,and improve the quality of life in patients undergoing intracranial hematoma evacuation.