Abstract: Objective To analyze the clinical effect of predictive nursing in the treatment of patients with hepatitis and hepatic coma,improve the methods of predictive nursing to promote nursing degree to provide evidence in future work. Methods The 64 cases of hepatitis and hepatic coma patients from Apr. 2011 to Apr. 2015 were divided into study group and controlled group by random number method.There were no difference between ages,disease,gender(P>0.05).The controlled group was treated with common nursing,the study group was treated with predictive nursing based on common nursing,including establishing predictive nursing awareness,controlling nitrogen source and preventing complication to ensure patients in good condition.The coma duration,death,incidence of complications of these two groups were compared. Results The coma duration of study group was (3.02±1.13)d,and there were 3 deaths and 2 incidence of complication.The coma duration of controlled group was (7.56±1.84)d,and there were 7 deaths and 12 incidence of complication.The coma duration,death,incidence of complications of study group were all better than controlled group (P<0.05). Conclusion Treating patients with hepatitis and hepatic coma with predictive nursing can improve clinical effect,short coma duration,decrease rate of death and incidence of complication with better effect to extend in clinic.