Abstract: Objective To retrospectively analyze the clinical diagnosis of spinal granuloma confirmed by pathology after surgical debridement. Methods The ESR,C-reactive protein,blood and other laboratory tests of the patients with the symptoms and dysfunction and spinal placeholder were detected.The lateral X-ray of the spine pathological segment was used to identify and exclude spinal tumors and tuberculosis and other diseases.MRI scans were performed sagittal,coronal and axial position scanning,better display the range of lesion structure,adjacent to its relationship with its surrounding soft tissue epidural,spinal cord violations and oppression.CT and 3D reconstruction clear the scope and damage by the spinal lesion,assisting MRI to further clarify the indications for surgery.All imaging data are read by more than two senior doctors of Spine Surgery and Radiology.Clearly determine the condition and surgery indication.The pathological examination was made after surgery for the final diagnosis of the disease. Results Excluding tuberculosis,spinal tumor,the 23 cases were inflammatory granuloma confirmed by pathology after surgical debridement.There foamy histiocytosis,plasma cells and lymphocytes pro-Yun,bleeding and colorectal lesions hoof tissue.Distinguish pathological changes from tuberculosis and cancer. Conclusion It is critical in clear the nature and characteristics of Detailed imaging studies preoperative.MRI,CT and other tests have an important role in the preoperative diagnosis.Not only to distinguish the tuberculosis cancer and other diseases is necessary,but also in the scope of violations of lesions,the impact on the relationship between the spinal cord and adjacent soft tissue lesions and displayed on different levels of spinal vertebrae and spinal damage erosion has an important role in diagnosis.Final pathology results,which can be combined with the former in diagnosis inflammatory granuloma.