Abstract: Objective To study the changes blood fat level and liver damage in schizophrenia patients after the long-term application of antipsychotic agents. Methods The clinical data of 120 cases of schizophreniain our hospital from December 2012 to December 2013 were collected.75 patients taking antipsychotic drugs more than 5 years were assigned into the observation group,while 45 patients taking antipsychotic drugs less than 5 years were assigned into the control group.Eighty healthy volunteers were recruited as healthy group.B ultrasound and blood lipid detection were performed in all 3 groups. Results The incidence of liver damage in the observation group(37.33%) was higher than that in thecontrol group(26.67%) and health group(3.80%),the difference was statistical significance(P<0.05).The cases with fatty liver in the observation group(24%) were more than that in the control group,and so were the number of severe fatty liver(8%).The incidence of fatty liver and severe fatty liver in the control group was higher than those in thehealthy group.The cases with an elevated blood fat in the observation group(18.67%) were more than the control group(11.11%) and healthy group 3.75%).In the observation group,the middle and old patients(more than 55 years) or with a longer course(more than 7 years) were with a higher incidence of fatty liver(38.89% and 35.71%),the difference was statistical significance(P<0.05). Conclusion Through the antipsychotics agents show good the rapeutic effect on schizophrenia,but the long-term application of antipsychotic agents can lead to the increase of blood fat level and liver damage(fatty liver).The timely detection and prevention measures should be taken in schizophrenia patients with a long-term application of antipsychotic agents.