Abstract: Objective To study the application value of continuous blood purification(CBP) therapy in the treatment of patients with severe sepsis,to provide the basis for clinical use of blood purification in the treatment of sepsis,and provide effective treatment for patients with severe sepsis. Methods Fifty-eight cases of severe sepsis patients were randomly selected from August,2013 to August,2015 in our hospital were divided into observation group(n=29) and control group(n=29).Control group were given the conventional treatment,however,in addition to conventional treatment,the observation group were given the CBP therapy 72 h.Symptoms,signs,serum biochemical indicators,inflammation index level and disease severity scores were compared between the two groups. Results The conventional therapy plus treatment with CBP effectively alleviate the patients with fever,palpitation,chest tightness,shortness of breath and symptoms of irritable,organs such as heart renal function indexes improved steadily,internal environment imbalances be corrected and stable,the expression of PCT,TNF-α,IL-8,CRP and other inflammatory factors were significantly decreased.At the same time,the body temperature,heart rate,WBC and other systemic inflammatory response indicators and blood biochemical and metabolic indicators were significantly improved,and Improvement of cyclic oxygenation,Lactic acid levels were significantly decreased,APACHE-Ⅱ,MODS and SOFA score were decreased,significantly improve the survival rate.The Symptoms,signs,serum biochemical indicators,inflammation index level and disease severity scores of observation group were significantly better than the control group(P<0.05). Conclusion Excessive inflammatory factor and toxin could be effectively removed by CBP,which corrected internal environment acid-base balance,the balance of the cell factor,improve the inflammatory reaction,and can improve the function of patients with monocytes.Furthermore,CBP blocked the development of SIRS to MODS,and promoted the organ function recovery.At last,mortality could be reduced by the use of the CBP.