Abstract: Objective To investigate the clinical effect of Vitamin D with rehabilitation on the cerebral palsy children with language dysfunction. Methods A total of 82 consecutives cases of cerebral palsy children with language dysfunction in our hospital from March 2011 to June 2014 were divided into purely rehabilitation group(n=39) and Vitamin D assisted with rehabilitation(combined group,n=43) by random number method according to the sequences of arriving into the hospital.The conventional rehabilitation therapy included physical therapy,massage,language training and so on;Shuangjing vitamin D drops were used in the combined group by one pill per-time and per-day,three months as a period.The condition changes of patients were observed.The language development situation,Gesell Child Development Scale,Bayley Infant development scale and serum Vitamin D,calcium levels after three months of treatment were compared between the two groups. Results In combined group,the total efficacy rate of language development situation was significantly higher(95.3% vs. 74.4%,χ²=7.213,P=0.007),the developmental quotient DQ score by Gesell Child Development Scale was higher[(70.4±11.3) vs.(53.3±10.5),t=6.127,P=0.026],the normal children rate was significantly more (41.9% vs. 20.5%,F=4.304,P=0.038);the excellent ratio of development index by Bayley Infant development scale was better (F=9.202,P=0.002),and the levels of serum Vitamin D and calcium were significantly higher[ (78.9±23.8) pmol/L vs.(56.3±21.0)pmol/L,t=6.025,P=0.023;(1.9±0.4)mol/L vs.(1.3±0.1)mol/L,t=5.624,P=0.028]. Conclusion Vitamin D with rehabilitation can effectively improve the language function and development in cerebral palsy children with language dysfunction,the clinical value should be further studied.