Abstract: Objective To investigate the status and relted influence factors tooccupational health of general practitioners(GPs)in Yunnan province on the base of the empirical study of GPs occupational health in Yunnan province. Methods According to the development level of the economic and social and the basic conditions of the medical and health work in Yunnan province.We extracted 226 GPs at the grass-roots level according to the good,medium and poor by using stratified cluster sampling method as the research objects.The spot investigation was conduced by using the self-designed self-reported questionnaire,and the dat were analyzed with χ² test and Logistic regression model,statistical test level was α=0.05.The relted influence factors to occupational health of GPs were discussed. Results The proportion of the self-assessment in the unhealthy state of 32.00%(64/200)in the 200 effective questionnaires.Unconditioned logistic regression analysis for the level of 0.05,excluding level of 0.10.The model χ²=48.061,P＜0.001,Cox&Snell R²=0.214,Nagelkerke R²=0.299,the total verification rate reached 72.5%.The results of unconditioned logistic regression analysis showed that the following five factors could affect the occupational health of GPs:few opportunities for advancement(P=0.009),due to time pressure result in fret(P=0.009),increasingly heavy burden on work(P=0.028),greatly time pressure(P=0.032),easy to relax after go home(P=0.034). Conclusion The health status of grass-roots GPs in Yunnan province is in poor,the influence factors include the current not perfect title promotion mechanism ingrassroots medical institutions,less places and heavy workload.The relevant departments should improve the professional environment of GPs and take effective measures to protect the occupational health of GPs.