Abstract: Objective To explore the clinical value of carotid artery stenting(CAS)in the prevention of ischemic stroke(ICS). Methods A total of 96 patients with CAS in this hospital from February 2010 to December 2013 were selected and were randomly divided into two groups with 48 cases in each group,the control group was treated with drug alone,while the observation group accepted CASS.The level of triglyceride(TG),total cholesterol(TC),low-density lipoprotein(LDL),and CAS severity in both groups were detected before and after the treatment,the adverse events were also recorded. Results The difference of lipid levels between the two groups before the treatment was not statistically significant(P>0.05);after the treatment,TG,TC and LDL in the observation group was (1.42±0.36) mmol/L,(3.15±0.32) mmol/L and (2.01±0.24) mmol/L,respectively,and in the control group was (1.76±0.43) mmol/L,(3.96±0.92) mmol/L and (2.52±0.34) mmol/L,respectively,the difference was statistically significant(P<0.05);the rate of CAS severe in the observation group was 2.1%(1/48),while in the control group was 18.8%(9/48),the difference was statistically significant (P<0.05);the incidence of carotid transient ischemic attack(TIA),ICS,new discovery infarction and death in the observation group were significantly lower than those in the control group(P<0.05). Conclusion CASS can control the degree of stenosis in patients with CAS,and prevent the occurrence of ICS,thus is safe and effective treatment methods.