Abstract: Objective To explore the effectiveness of Shugan Jieyu capsule(SGJY) combined antipsychotics Sertraline(Ser)on the negative symptoms of Senile Schizophrenia(SSP). Methods Total 96 patients with SSP negative symptoms in this hospital between August,2012 and April,2015 were selected and randomized divided into two groups,48 cases in the observation group and the control group.The control group was treated with Ser,while the observation group with SGJY on the basis of control group.Before and after the treatment,the negative symptoms,positive symptoms,general psychiatric symptoms score and total score in two groups were evaluated,and the comprehensive effects of the two groups were evaluated,as well as the adverse reactions of the two groups were statistically analyzed. Results The difference of negative symptom score,positive symptoms score,general mental pathological symptom score and total score before the treatment was not statistically significant between the two groups(P>0.05);after the treatment,the negative symptom score,positive symptoms score,general psychiatric pathology symptom score and total score in the observation group was (9.4±3.2) points,(16.8±4.2) points,(10.9±3.8)points and (37.2±7.2) points,respectively,while in the control group was (12.6±4.1) points,(20.5±3.8) points,(14.3±3.6) points and (46.8±7.9) points,respectively,the score in the observation group were significantly lower than that in the control group(P<0.05);the efficiency in observation group was 95.8%(46/48),while in the control group was 81.2%(39/48),the observation group was significantly higher as compared with the control group(P<0.05);the adverse reactions rate in observation group was 8.3%(4/48),while in the control group was 12.5%(6/48),the difference was not statistically significant(P>0.05). Conclusion SGJY combined with Ser treatment can significantly improve symptoms in SSP patients with negative symptoms,the effect is significant.