Abstract: Objective To analyze the clinical manifestations of overweight and obese children in Wenzhou. Methods Cross section and case-control study were conducted in this study.Total 312 students in primary and high schools who received physical examination in our hospital between Jan.,2012 and Dec.,2014 were recrited and were divided into obesity group(109 cases),overweight group(89 caes)and normal weight group(114 cases).The anthropometric data(gender,age,height,weight),BMI,B-scan liver images,fasting blood glucose,fasting insulin,liver function,renal function,blood lipids profile,HOMA-IR and HOMA-B were recorded and analyzed. Results As compared with normal weight group,the levels of glutamic-pyruvictransaminase(GPT),glutamic-oxalacetictransaminease(GOT)and glutamyltranspeptidase(GGT)were significantly increased in overweight and obese group(P all <0.05).The levels of total cholesterol(TC),triglyceride(TG)and low density lipoprotein cholesterin(LDL-C)were higher but high density lipoprotein cholesterin(HDL-C)were lower in overweight and obese group when compared with those in normal weight group(P all <0.05).According to the ultrasoundresults ,the prevalence of non-alcoholic fatty liver(NAFLD)were 45% in obese group,which was higher than those in overweight(8%)and normal weight group(0%),P<0.01,respectively.HOMA-IR was significantly higher in overweight and obese group when compared with those in normal weight group(P<0.01,respectively). Conclusion The overweight and obesity children have the characteristics of insulin resistance,include theincreased levels of transaminase,dyslipidemia,and increased prevalence of nonalcoholic fatty liver disease(NAFLD).