Abstract: Objective To assess the curative effect of different treatment regimens and provide personalized therapy for leiomyoma of uterus. Methods The clinical data of 170 cases of intramural uterine myoma confirmed by ultrasound examination in our hospital between 2008 and 2013 were reviewed.The preoperative ultrasound or MRI was used to assess the conditions of patients and select the regimen.30 patients received uterine artery embolization(UAE),90 patients received transabdominal or laparoscopic hysteromyomectomy,and 50 patients received high intensity focused ultrasound.The curative effects were evaluated by ultrasound and MRI at the end of the treatment. Results The effectiveness of UAE,laparoscopic hysteromyomectomy and high intensity focused ultrasound were 46.7%,94.4% and 86.0%,respectively,the difference between UAE group and laparoscopic hysteromyomectomy group or high intensity focused ultrasound group was statistical significant(P<0.05),but not significant between laparoscopic hysteromyomectomy group or high intensity focused ultrasound group(P>0.05). Conclusion The curative of hysteromyomectomy and high intensity focused ultrasound is superior to UAE in the treatment of leiomyoma of uterus,but the high intensity focused ultrasound had certain limitations.