Abstract: In recent years,with the rapid development of the basic subjects,the traditional teaching methods cannot adapt to the new development in teaching of clinical oncology.In order to improve the teaching quality and adapt the new development situation and the transformation of medical model,new teaching method is needed to be used in clinical oncology teaching.PBL teaching method is a new teaching method which based on clinical cases and with problems as the guide;the teaching mode is submit questions first and then teach the content.This method guide the students to tackle problems through their independent inquiry and cooperation,it emphasizes the students’ subjective initiative,develop the ability to solve problems and the ability of autonomous learning.PBL teaching method is helpful to strengthen the training of students’ comprehensive quality.PBL teaching method also put forward higher requirements for teachers,promote teachers to strengthen the business level,expand the knowledge field,make the teachers’ knowledge structure to be more perfect and knowledge update more quickly,lead to an further improvement in teaching level.But the implement time of PBL teaching method in our country is not long,and is subject to the limits of our country’s education system,it is still a kind of new teaching method,in the exploratory stage and not formed mature system model,many teachers are insufficient understanding of PBL teaching mode.This article expound the application of the PBL teaching method in clinical oncology from these aspects:the application of PBL teaching method in medical education,the advantages compares to traditional teaching method,the concrete teaching scheme,the existing problems and solutions.By using new teaching methods in clinical oncology,it will achieve the objective of replacing traditional teaching mode by quality education mode,and cultivate excellent doctors to meet the needs of clinical oncology.