Abstract: Objective To analyze the prevalence and related factors of post-stroke depression(PSD) in each period of stroke. Methods Total 64 cases of first stroke were selected in our hospital.The Hamilton Depression Rating Scale(HAMD),daily life ability Rating Scale(ADL),social support rating scale(SSRS),neurological function impairment scale and Eysenck Personality Questionnaire(EPQ-RSC) were employed to assess the patients after 1 month,3 months,6 months and 12 months of admission and analyze the incidence of PSD in each time point and related factors. Results The incidence of PSD at 1 month,3 months,6 months and 12 months were 18.75%,29.03%,37.70% and 31.03%,respectively;the ratio of women and man with introverted personality in PSD patients after 1 month,3 months and 6 months was higher than that in non-PSD patients,with significant difference(P<0.05);The daily living score and social support score at 3 months,6 months and 12 months after stroke were significantly lower than that in the control group(P<0.05);The neurological deficit score in PSD patients was higher than that in the non-PSD patients(P<0.05).Logistic regression analysis showed that the incidence of PSD at 1 month after stroke was associated with the characteristics of introvert and female gender(P<0.05),at 3 months with women,daily life,social support and neurological deficits(P<0.05),and at 12 months with the daily life,social support and neurological deficits(P<0.05). Conclusion The incidence of depression in stroke patients is high.We should pay close attention at early stage to women and patients with introverted personality in the clinical diagnosis,and at middle and late stage strengthen the monitor of daily life ability and social support and severe neurological deficit,taking early prevention and treatment methods to reduce the incidence of PSD.