Abstract: Objective To evaluate the outcomes and postoperative complications of laparoscopic surgery and open surgery for colonic cancer. Methods The reported randomized controlled trials on the outcomes and postoperative complications of laparoscopic versus open surgery for colonic cancer between Jan.2005 and Jan.2015 were collected by searches of CNKI and VIP.The criteria of literature enrollment and exclusion was made,strictly according to which the literatures were screened.Data were extracted from these literatures,and data analysis was performed by RevMan 4.7. Results A total of 2 766 patients from 25 literatures was selected,including 1 392 patients in the laparoscopic surgery group and 1 374 patients in the open surgery group.Except body mass index,the age and gender were similar between the two groups.The results of this Meta-analysis indicate that the operation time and number of lymph node dissection in both group had no statistical differences(P>0.05),while the intraoperative blood less,intestinal function recovery time,average time of hospital stay were evidently lower and shorter than the patients in the open surgery group(P<0.05).Moreover,the incidences of intestinal obstruction and intestinal fistula were lower than the open group(P<0.05).There was no statistically significant difference in the Long-term outcomes between the two groups(P>0.05),including recurrence rate in 5 years,survival rate in 3 years and 5 years. Conclusion The long-term outcomes of laparoscopic surgery group are similar to that of open surgery group for colon cancer,however,the laparoscopic surgery group has obvious advantages in short-term outcomes and postoperative complications.Therefore,laparoscopic surgery for colon cancer is an acceptable alternative.