Abstract: Objective To evaluate the curative effect of desonide cream combined with Multi embellish skin care agent for chronic eczema. Methods Seventy-eight patients were randomly divided into treatment group and control group.Forty-two cases in treatment group were treated with desonide cream and Multi embellish skin care agent,each twice a day.Thirty-six cases in control group were trated with desonide cream,twice a day,two groups are using 4 weeks.Before and after treatment,the total score of the site,symptoms and skin lesions were evaluated according to EASI score.Adverse drug reactions were observed and recorded during the course of treatment.The recurrence rate of cured cases was assessed after 2 months. Results In the treatment group of 42 cases,28 cases were cured,10 cases had marked effect;In the Control group of 36 cases,15 cases were cured,9 cases had marked effect.Two groups of curative effect comparison difference was statistically significant(Z=-2.759,P<0.05).The recurrence rate of cured cases was assessed after 2 months,In treatment group of 28 cases,2 cases of recurrence,the recurrence rate was 7.1%.In the control group of 15 cases,5 cases of recurrence,the recurrence rate was 33.3%.The recurrence rates in the two groups had statistically significant difference(the use of Fisher's exact probability method,P<0.05).There were no obvious adverse reaction in two groups. Conclusion Desonide cream combined with Multi embellish skin care agent in the treatment of chronic eczema has better curative effect and high safety.