Abstract: Objective To explore the levels of plasma Hcy and QRS duration in coronary heart disease (CHD) patients with heart failure(HR),and analyze the correlation between them. Methods Total 110 cases CHD patients with heart failure in the observation group were divided into Ⅱ,Ⅲ,Ⅳ subgroups according to the NYHA class.The patients with stable coronary artery disease angina were selected as the CHD control group,the non-CHD patients with heart failure were selected as the heart failure control group,and the healthy volunteers were as healthy control.The cardiac function index,levels of brain natriuretic peptide(BNP) and Homocysteine(Hcy),and QRS wave duration of all the subjects were measured. Results The levels of BNP and Hcy,LVEDD and QRS duration in the observation group,HF control group and CHD control group were significantly higher than that of healthy control group,LVEF was significantly lower than that in the healthy control group,the differences were statistically significant(P<0.05);the levels of Hcy and QRS duration with Ⅲ and Ⅳ heart function class were significantly higher than that with the Ⅱ heart function class,Hcy level and QRS duration in Ⅳ heart function class were significantly higher than the Ⅲ heart function class,the differences were statistically significant(P<0.05);Pearson correlation analysis showed that Hcy level and QRS duration were significantly positive correlation(P<0.001;Hcy level and QRS duration were positively related to BNP level and LVEDD,and negative correlated with LVEF. Conclusion The level of plasma Hcy is significantly high in CHD patients with heart failure,and increase with the NYHA class.Hcy level is significantly positively related to QRS duration.The combined tests of Hcy level and QRS duration can be used as an important index in evaluating the cardiac function status of CHD patients with heart failure.