Abstract: Objective To explore the changes of blood coagulation function in patients with acute pancreatitis and its clinical significance. Methods Total 67 cases patients with acute pancreatitis in our hospital from January,2013 to June,2014 were enrolled and assigned into observation group,and further divided into mild group(MAP group),severe group(SAP group),multiple organ dysfunction syndrome(MODS) and non-MODS group.35 healthy volunteers at the same period in our hospital were recruited as control group.Prothrombin time(PT),part of the activation of prothrombin time(APTT),concentration of fibrinogen(FIB) and D-dimer(D-D) were tested and compared.The relevance to acute physiology and chronic health evaluation(APACHEⅡ) was analyzed. Results The blood coagulation function index and APACHEⅡ score in the observation group were significantly higher than that in the control group,the BPC was significantly lower than that in the control group,the difference was statistically significance(P<0.05);The blood coagulation function index and APACHEⅡ score in SAP group were significantly higher than that in MAP group,the BPC was significantly lower than that in MAP group,the blood coagulation function index and APACHEⅡ score in MODS group were significantly higher than that in non-MODS group,the BPC was significantly lower than that in non-MODS group,the difference was statistically significance(P<0.05);Pearson correlation analysis showed that blood coagulation function index of PT,APTT,FIB and D-D were positively related to the APACHEⅡ score,while BPC was significantly negative related to the APACHEⅡ score(P<0.05). Conclusion There is blood coagulation dysfunction in patients with acute pancreatitis,it's closely associated with the severity and prognosis of diseases.