Abstract: Objective To evaluate the status quo and the rationality of the drug utilization in hospitalized patients with chronic hepatitis B,and provide reference for rational clinical usage of drugs. Methods The methods of drug utilization review(DUR)and drug utilization evaluation(DUE) were used to analyze the drug utilization index(DUI),drug application situation,monitoring of therapeutic process as well as therapeutic outcome of chronic hepatitis B hospitalized in our hospital. Results Total 97 cases of patients with hepatoprotective 17 species and 21 varieties and specifications,DDDs of the top 3 drugs were polyene phosphatidylcholine injection,injection with succinic acid adenosine methionine and injection with compound glycyrrhizin.The DUIs of 5 kinds of drugs were more than 1,DUI=1 was found in 13 kinds;and DUI<1 was found in 3 kinds.Single,double,triple and quadruple drug constituent ratio were 30.93%(30/97),46.39%(45/97),17.53%(17/97)and 5.15%(5/97),respectively,corresponding to the recovery or improvement of liver function in patients with constituent ratio were 70.00%(21/30),91.11%(41/45),82.35%(14/17)and 60.00%(3/5).The study subjects were in line with the pathogen and clinical stage,and only 3.09%(3/97)were confirmed by pathological stage.97 patients had abnormal liver function,the monitoring rate of liver function was 100.00%(97/97),93 patients with the clinical symptoms improved after treatment with anti-inflammatory and hepatoprotective,liver function was restored to normal in 79 patients. Conclusion DUR combined with DUE can be more comprehensive evaluation of drug utilization of the patients with chronic hepatitis B.The usage of hepatoprotective drugs in hospitalized patients with chronic hepatitis B in our hospital is basically reasonable,and double therapy may achieve a good therapeutic effect.