Abstract: Objective To explore the preventive effect of Parecoxib sodium(Par) combined with Tramadol (TR) for postoperative analgesia in Gynaecological Laparoscopic surgery(LS). Methods Total 82 cases undergoing surgical treatment in our hospital from August,2014 to March,2016 were selected,and randomly divided into the observation group and the control group with 41 cases in each group.The control group was intravenous injected 2 mg/kg Tramadol at 30 min before the end of surgery,while the observation group was treated with 40 mg Par 30 min before surgery on the basis of control group.The visual analog scale(VAS) at 0.5 h,4 h,12 h and 24 h postoperative,spontaneous breathing recovery time,consciousness recovery time,time to extubation,and incidence of adverse reactions of two groups were recorded and compared. Results VAS score at 0.5 h,4 h,12 h and 24 h after surgery in observation group were (1.7±0.5) points,(1.9±0.8) points,(1.7±1.0) points and (1.2±0.4) points,respectively,while in the control group were (3.2±0.6) points,(3.4±1.0) points,(3.1±0.8) points and (1.9±0.6) points,respectively,VAS scores of each check-point in the observation group were significantly lower than the control group(P<0.05);there was no significant difference in the recovery time of spontaneous breathing,consciousness recovery time and time to extubation between the two groups(P>0.05);the incidence of adverse reaction was 7.3%(3/41) in the observation group,while was 9.7%(4/41) in the control group,the difference between the two groups was not statistically significant(P>0.05). Conclusion Par combine with TR in LS has a significant preventive effect for early postoperative pain,and with high safety,worthy of further promotion in clinical practice.