Abstract: Objective To investigate the depression level of the daughters or sisters of the hospitalized breast cancer patients,and provide the scientific bases for the prevention and cure of depression. Methods We finally investigated 105 female person,who was the daughter or sister of the hospitalized breast cancer patients,with the Self-rating Depression Scale(SDS).The collected data was analyzed by descriptive/chi-square test/Logistic analysis. Results There were 100 effective responses.The main depression scoreof these 100 person was 44.61±11.29,which compared with the domestic norm(41.88±10.57/41.54±10.54)had statistical significance(P<0.05).Twenty cases were with depression,the prevalence rate was 20%.The single-factor logistic regression showed that the patient's treatment stage,age,role;Binary Logistic regression indicated that age,the patient's treatment stage were the risk factors,and the regression equation can explain 14.7% of the variance. Conclusion The depression of the breast cancer patients' primary relatives have the poor status.The nurse or the community nursing care workers should pay more attention on the psychological health of such a target group.