Prevalence and associated risk factors of hyperuricemia and gout in Han,Uygur,Kazak,Xibe of Xinjiang Ili Kazak Autonomous Prefecture
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摘要: 目的 探讨新疆伊犁哈萨克自治州汉族、维吾尔族、哈萨克族、锡伯族人群高尿酸血症与痛风患病率及相关危险因素。 方法 2014年12月—2016年1月对3 500例新疆伊犁哈萨克自治州居住者进行流行病学调查,对总体患病情况、血尿酸水平、痛风患病情况、高尿酸血症患病影响因素进行分析。 结果 ①3 318例纳入调查对象中,共有662例高尿酸血症患者,总患病率为19.95%(662/3 318);其中男性患病率为23.45%,女性患病率为16.78%(292/1 740);男性高尿酸血症患病率显著高于女性(P<0.01);②男性血尿酸水平平均值为(382.17±56.37)μmol/L,女性为(290.09±39.77)μmol/L,男性血尿酸水平显著高于女性(P<0.05);③本研究中纳入的3 318例调查对象中,发生痛风数52例,痛风总患病率为1.57%,其中男性患病率为2.79%,女性患病率为0.46%,男性痛风患病率显著高于女性(P<0.05)。汉族痛风患病率显著高于其他少数民族(P<0.05);④经Pearson单因素分析,患者组与对照组在吸烟、饮酒、经常运动、肥胖、血脂紊乱、高胆固醇血症、高血压及服用阿司匹林方面的差异均具有统计学意义(P<0.05~0.01);采用多元Logistic回归分析,最终确定影响高尿酸血症患病的相关因素为:饮酒、肥胖、血脂紊乱、高血压及口服阿司匹林。 结论 影响高尿酸血症与痛风患病的相关因素较多,应对这些影响因素进行观察,并采取相应措施,以降低高尿酸血症与痛风的患病率。Abstract: Objective To investigate prevalence and associated risk factors of hyperuricemia and gout in the Han,Uygur,Kazak,Xibe of Ili Kazak Autonomous Prefecture and gout. Methods From December 2014 to January 2016,3 500 cases of Xinjiang Ili Kazak Autonomous Prefecture occupants epidemiological survey,the overall prevalence of blood uric acid level,the prevalence of gout,hyperuricemia prevalence influencing factors analysis. Results ①3 318 cases included in the survey,a total of 662 cases of hyperuricemia in patients with total prevalence rate was 19.95%(662/3 318);male prevalence rate was 23.45%,female prevalence rate was 16.78% (292/1 740);male hyperuricemia prevalence was significantly higher than females(P<0.01);②the average male serum uric acid level was (382.17±56.37) μmol/L,women (290.09±39.77) μmol/L,male serum uric acid levels were significantly higher than females(P<0.05);③in this study included 3 318 cases of the survey,the number of 52 cases occurred gout,gout prevalence rate of 1.57% total,of which men suffering disease was 2.79%,0.46% prevalence of women,the prevalence of gout in men was significantly higher than females(P<0.05).Han gout prevalence was significantly higher than that of other minorities(P<0.05);④by Pearson univariate analysis,patient and control groups in smoking,drinking,regular exercise,obesity,dyslipidemia,hypercholesterolemia,high aspirin and blood pressure differences were statistically significant aspects(P<0.05-0.01);multivariate Logistic regression analysis,and ultimately determine the relevant factors for the prevalence of hyperuricemia:drinking,obesity,dyslipidemia,hypertension and oral aspirin. Conclusion The factors affecting the prevalence of hyperuricemia and gout are more to address these factors were observed,and take appropriate measures to reduce the prevalence of hyperuricemia and gout.
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Key words:
- Hyperuricemia /
- Gout /
- Risk factors
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