Abstract: Objective Heat sensitive moxibustion on knee osteoarthritis has good effect,but it is time-consuming. Therefore, heat sensitive moxibustion is often operated only for local in patients, without more time for overall adjustment. This study uses heat sensitive moxibustion combined with relative acupuncture in order to treat combination of local and global. The effect will be observed if they are better than only heat sensitive moxibustion. Methods All of the subjects were from outpatient in January,2014 to January,2015.Sixty cases eligible patients with osteoarthritis of the knee were randomly divided into treatment group and control group,30 cases in each group.The control group was treated with the method of simple heat sensitive moxibustion,which was used to heat sensitive moxibustion at inside and outside xiyan points in the around the affected side of the knee.The treatment group were treated with heat sensitive moxibustion combined with relative acupuncture,first using of relative acupuncture method,which select four pairs of points such as inside and outside xiyan points,Xuehai and Liangqiu,Yanglingquan and yinlingquan,Taichong and Taixi,retaining needle for 30 min,and then heat sensitive moxibustion.Five times treatment were operated each week, but rest at the weekend,totalled 3 courses.Effect,visual pain score (visualanalogscale,VAS) and Lysholm knee score (Lysholm knee score,LKSS) were observed before and after treatment. Results The total efficiency of treatment group was 93.33%,but 76.67% in the control group.The difference was statistically significant(P<0.05) using the rank sum test.VAS and Lysholm knee score after treatment were significantly improved compared with before treatment,and it in the treatment group was statistically significant difference with control group(P<0.05). Conclusion There were good role in effect,relieving pain and improving functional activity for heat sensitive moxibustion on the intervention of knee osteoarthritis.But heat sensitive moxibustion combined with relative acupuncture has a more synergistic effective than simple heat sensitive moxibustion on the intervention of knee osteoarthritis.