Abstract: Objective To analyze the etiology,prevention and treatment measures of corneal haze after the excimer laser corneal surgery(Laser Assisted Sub-Epithelial Keratomileusis,LASEK). Methods The clinical data of 50 cases undergoing LASEK between June 1,2013 and December 31 were analyzed retrospectively. LASEK was performed in 92 eyes.The follow-up of 12 months was carried out to study the incidence and severity of corneal haze. Results After LASEK,corneal hazeoccurred in 36 eyes(39. 1%) with an average grade of 0. 81 ±0. 48,and the diopter of 20 eyes was greater than- 5. 0 D. The local non-steroidal anti-inflammatory therapy and Corticosteroid were administrated and UV was avoided. Six months later,3 eyes were with corneal haze(3. 3%) with an average grade of 0. 5. 24 of 36 eyes with haze received LASEK in summer. Conclusion LASEK is a safe and effective operation for the treatment of high myopia. The complications such as severe haze are closely related to high myopia,allergies,autoimmune diseases,andfrequent exposure to ultraviolet light. The carefully preoperative screening and strictly control the indications will ensure the successful operation. The regular follow-up and reexamination can monitor the occurrence and development of haze,and adjust the dose of medicines according to theseverityandintraocular pressure. The effective nursing measures will also decrease the incidence of haze and improve the prediction and accuracy of LASEK.