Abstract: Objective To investigate the prevalence of common chronic diseases among the college staffs,and provide reference for the scientific management of chronic diseases. Methods A total of 6 440 referral reimbursement receipts to the higher level hospital were chosen to establish a database through Epidata and analyzed with SPSS. Results The top ten of morbidity were hypertension,coronary heart disease,hyperlipidemia,diabetes,cerebral vascular disease,osteoporosis,bone and joint disease,mental disorders,chronic renal function insufficiency,chronic gastroenteritis. 59. 59% of the referral patients were chronic patients and the prevalence increased with age(χ²trend=346. 728,P < 0. 001). But the gender difference was not significant(χ²=2. 726,P=0. 101). The treatment number of chronic patients was 3 times that of nonchronic ones in the study time period. Of the total cost,89. 64% was for the chronic patients. The average cost by chronic patients was nearly twice as much as the non-chronic ones. And,the medicine cost by chronic patients accounted for75. 33%. Among the chronic patients,53. 85% suffered at least 3 kinds of diseases. The total number diseases suffered by chronic patients had a significant effect on the average cost(χ²trend=287. 209,P < 0. 001). Conclusion The college hospital is a main position to prevent and control the chronic diseases. Therefore,to improve the availability of the commonly used medicine and formulate chronic disease stratification strategy of health management can help them to play a greater role as the 'Health Keeper'.